摘要
Abstract
Objective:To explore the clinical application effect of Levofloxacin combined with anti-tuberculosis regimen in patients with pulmonary tuberculosis.Method:A total of one hundred and two pulmonary tuberculosis patients who were questioned and treated in Yangzhou Third People's Hospital from May 2017 to May 2022 were selected for inclusion in this study,and they were divided into control group(fifty-one cases)and study group(fifty-one cases)according to the computerized random number table method.The control group received conventional anti tuberculosis regimen treatment,and the study group received Levofloxacin combined with conventional anti-tuberculosis regimen treatment.Efficacy,sputum turn negative rate,pulmonary function,immune index levels,and medication safety between the two groups were compared.Result:The treatment total effective rate of the study group was higher than that of the control group,the difference was statistically significant(P<0.05).After 1 month,3 and 6 months,the sputum turn negative rates in the study group were higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of forced expiratory volume in one second(FEV1)/forced vital capacity(FVC)%,peak expiratory flow(PEF),and FEV1 in both groups were higher than those before treatment,and those in the study group were higher than in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of CD3+,CD4+/CD8+ in both groups were higher than those before treatment,and those in the study group were higher than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse effects between the two groups(P>0.05).Conclusion:Treatment with Levofloxacin combined with anti-tuberculosis regimens for pulmonary tuberculosis can obviously improve the efficacy and the rate of sputum turn negative of patients,improve the pulmonary function and immune index levels,increase Levofloxacin treatment will not obviously increase the adverse effects,the use of the drug has a high safety.关键词
肺结核/左氧氟沙星/痰液转阴率/肺功能/免疫/用药安全性Key words
Pulmonary tuberculosis/Levofloxacin/Sputum turn negative rate/Pulmonary function/Immunity/Medication safety
