摘要
Abstract
Objective:To investigate the effect of Wenxin Granules combined with Levosimendan in the treatment of myocardial infarction combined with ventricular arrhythmia and its influence on heart rate variability.Method:Eighty-six patients with myocardial infarction combined with ventricular arrhythmia admitted to the Third People's Hospital of Jingzhou from March 2020 to June 2021 were selected and divided into the observation group(43 cases)and the control group(43 cases)by random number table method.The control group was treated with Leosimendan,the observation group was supplemented with Wenxin Granules on the basis of control group.The QT dispersion(QTd),the indexes of the heart rate variability,coagulation factor,serum inflammatory factor and total effective rate were compared between the two groups.Result:Before treatment,there were no significant differences in QTd,tumor necrosis factor-α(TNF-α),interleukin-17(IL-17)and hypersensitive C reactive protein(hs-CRP)between the two groups(P>0.05);after treatment,the above indexes in the two groups were lower than those before treatment,and the above indexes in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,the standard deviation of sinus beats of R-R interval(SDNN),root mean square of adjacent sinus beats R-R interval difference(RMSSD),percentage of R-R interval difference between adjacent sinus beats greater than 50 ms(PNN50),sinus beats standard deviation of average R-R interval(SDANN),standard mean of sinus beats R-R interval(SDNNI)were compared between the two groups,the differences were not statistically significant(P>0.05);after treatment,the above indexes in the two groups were higher than those before treatment,and the above indexes in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences between the activated partial thromboplastin time(APTT),prothrombin time(PT)and fibrinogen(Fbg)of the two groups(P>0.05);after treatment,the APTT and PT of the two groups were longer than those before treatment,the above indexes of the observation group were longer than those of the control group,and the Fbg in two groups were lower than those before treatment,and the observation group was lower than that of the control group,the differences were statistically significant(P<0.05).The total effective rate(95.35%)in the observation group was higher than that of the control group(81.40%),the difference was statistically significant(P<0.05).Conclusion:Wenxin Granules combined with Levosimendan can effectively improve heart rate variability,strengthen cardiac function,optimize coagulation status,and reduce the expression of serum inflammatory factors in patients with myocardial infarction complicated with ventricular arrhythmia.关键词
稳心颗粒/心肌梗死/室性心律失常/心率变异性/血清炎症因子Key words
Wenxin Granules/Myocardial infarction/Ventricular arrhythmia/Heart rate variability/Serum inflammatory factor
