中国医学创新2023，Vol.20Issue(35)：145-150,6.DOI:10.3969/j.issn.1674-4985.2023.35.033
血清vaspin、sVCAM-1、MCP-1、IL-6、hs-CRP水平与急性脑梗死患者颈动脉粥样硬化程度的相关性及对血管风险事件的预测价值
Correlation between Serum vaspin,sVCAM-1,MCP-1,IL-6,hs-CRP Levels and the Degree of Carotid Atherosclerosis in Patients with Acute Cerebral Infarction and Its Predictive Value for Vascular Risk Events
摘要
Abstract
Objective:To investigate the correlation between serum visceral adipose-specific serine protease inhibitor(vaspin),soluble vascular cell adhesion molecule-1(sVCAM-1),monocyte chemotactic protein-1(MCP-1),interleukin-6(IL-6)and hypersensitive C reactive protein(hs-CRP)levels and the degree of carotid atherosclerosis(CAS)in patients with acute cerebral infarction(ACI)and its predictive value for vascular risk events.Method:A total of 106 ACI patients were admitted to Lianyungang Oriental Hospital from January 2021 to January 2022 were selected as the ACI group,and 55 healthy physical examination people at the same time were selected as the control group.Serum levels of vaspin,sVCAM-1,MCP-1,IL-6,hs-CRP were tested in all subjects,serum indicators levels of patients with different CAS degrees were compared between the two groups and ACI group.The correlation between serum vaspin level and CAS degree and all indicators to their predictive value for vascular risk events were analyzed.Result:The serum vaspin level in the ACI group was lower than that in the control group,sVCAM-1,MCP-1,IL-6,hs-CRP were higher than those in the control group,the differences were statistically significant(P<0.05).As the degree of CAS increased,the serum vaspin levels of patients were decreased,the difference was statistically significant(P<0.05).Spearman correlation analysis showed a negative correlation between serum vaspin levels and the degree of CAS in ACI(rs=-0.325,P<0.05).A total of 18 cases(16.98%)of 106 patients with ACI had vascular risk events,univariate analysis showed that patients with vascular risk events had statistically significant differences in age,history of hypertension,history of diabetes,smoking history,serum vasopin,sVCAM-1,MCP-1,IL-6,hs-CRP compared to those patients without vascular risk events(P<0.05).Multivariate logistic regression analysis showed that serum sVCAM-1,MCP-1,IL-6 and hs-CRP were the independent risk factors for vascular risk events in ACI patients(P<0.05),vaspin was protective factor for vascular risk events in ACI patients(P<0.05).The receiver operating characteristic(ROC)curve showed that the areas under the curve for predicting vascular risk events in ACI patients with serum vaspin,sVCAM-1,MCP-1,IL-6,and hs-CRP were 0.822,0.751,0.698,0.727,0.769,respectively(P<0.05).Conclusion:The level of serum vaspin in ACI patients is relatively low,and this indicator is negatively correlated with the degree of CAS,serum vaspin,sVCAM-1,MCP-1,IL-6,hs-CRP have high predictive value for the occurrence of vascular risk events in patients with ACI.关键词
内脏脂肪特异性丝氨酸蛋白酶抑制剂/急性脑梗死/颈动脉粥样硬化/血管风险事件/相关性/预测价值Key words
Visceral adipose-specific serine protease inhibitor/Acute cerebral infarction/Carotid atherosclerosis/Vascular risk events/Correlation/Predictive value引用本文复制引用
安仲武,薄维波,李欣,常焕显..血清vaspin、sVCAM-1、MCP-1、IL-6、hs-CRP水平与急性脑梗死患者颈动脉粥样硬化程度的相关性及对血管风险事件的预测价值[J].中国医学创新,2023,20(35):145-150,6.基金项目
江苏省卫生健康委科研项目(M2021100) （M2021100）
南京医科大学康达学院科研发展基金(KD2022KYJJZD135) （KD2022KYJJZD135）
