摘要
Abstract
Objective To explore the therapeutic effects of radiotherapy combined with Karelizumab immunotherapy and radiotherapy combined with Tegafur chemotherapy in locally advanced esophageal cancer patients.Methods Eighty locally advanced esophageal cancer patients admitted to Hefei Cancer Hospital Chinese Academy of Sciences between January 2020 and December 2022 were randomly selected.According to the treatment method,the patients were divided into two groups:the control group(40 cases)and the observation group(40 cases).The control group received radiotherapy combined with the Tegafur chemotherapy regimen,while the observation group received radiotherapy combined with Karelizumab treatment.Clinical efficacy,immune function,tumor marker levels,medication safety,and quality of life were compared between the two groups.Results The Objective Response Rate(ORR)and Disease Control Rate(DCR)of the observation group were higher than those of the control group(P＜0.05).Aftertreatment,thelevelsof CD3+and CD4+/CD8+in both groups were higher than before treatment and the level in the research group was higher than that in the control group(P＜0.05).After treatment,the levels of carcinoembryonic antigen(CEA)and carbohydrate antigen 724(CA724)in both groups were lower than before treatment,and the observation group was lower than the control group(P＜0.05).There was no statistically significant difference in adverse effects between the two groups(P＞0.05).After treatment,the KPS scores of both groups were higher than before treatment,while the observation group was higher than the control group(P＜0.05),and the QLQ-OES18 scores of both groups of esophageal cancer patients were lower than before treatment,and the observation group was lower than the control group(P＜0.05).Conclusions Treatment with radiotherapy plus Karelizumab in the clinical management of patients with locally advanced esophageal cancer significantly improves treatment outcomes,immune function and tumour marker levels,and quality of survival.The concomitant medication had a better safety.关键词
局部晚期食管癌/放疗/替吉奥/卡瑞利珠单抗/免疫功能/T淋巴细胞亚群Key words
Locally advanced esophageal cancer/Radiotherapy/Tegafur/Karelizumab/Immunological functioning/T lymphocyte subsets
