中国肿瘤外科杂志2023，Vol.15Issue(6)：567-571,5.DOI:10.3969/j.issn.1674-4136.2023.06.008
旋转容积调强放疗在脑转移瘤患者全脑+同步推量放疗中对海马区保护及认知功能的影响
Effect of volumetric modulated arc therapy on the protective effect and cognitive function of hippocampus in the whole-brain+simultaneous integrated boost radiotherapy for patients with brain metastases
卢峰 1李璐璐 1张飞 1牛雷雷 1李太平1
作者信息
- 1. 236000 安徽 阜阳,阜阳市肿瘤医院 放疗科
- 折叠
摘要
Abstract
Objective To explore the effect of Volumetric Modulated Arc Therapy(VMAT)on the protective effect and cognitive function of the hippocampus in the whole-brain+Simultaneous Integrated Boost radiotherapy for patients with brain metastases.Methods A retrospective analysis was conducted on the medical records of 76 brain metastase patients admitted to the Fuyang Cancer Hospital from March 2019 to December 2021.Based on the radiotherapy regimens,the patients were divided into a research group and a control group.The research group,40 patients,received whole-brain+simultaneous integrated boost radiotherapy using VMAT.The control group,36 patients,received conventional whole-brain radiotherapy plus an intracranial lesions boost radiotherapy.A one-year follow-up was conducted to compare the hippocampal radiation dose,short-term efficacy,adverse reactions,cognitive function,and survival outcomes between the two groups.Results The maximum and average radiation doses in the hippocampus of the patients in the research group were lower than those in the control group(P＜0.05).The disease control rate(DCR)of the research group patients was 95.00%,which was higher than that of the control group(77.78%,P＜0.05).The incidence of neurological toxicity in the research group was lower than that in the control group(P＜0.05).After 3 months of radiotherapy,the cognitive function score of the control group patients was lower than before radiotherapy(P＜0.05);The cognitive function score of the research group patients was higher than that of the control group(P＜0.05).The 1-year survival rate of the research group was higher than that of the control group(P＜0.05),and there was a statistically significant difference in the progression-free survival(PFS)curve between the two groups(P＜0.05).Conclusions The application of VMAT technology in the whole-brain+simultaneous integrated boost radiotherapy for patients with brain metastases helps reduce the dose in the hippocampus,reduce the risk of cognitive impairment,and extend the survival period of patients.关键词
脑转移瘤/旋转容积调强放疗/全脑放疗/同步推量放疗/海马区/认知功能Key words
Brain metastases/Volumetric modulated arc therapy/Whole brain radiotherapy/Simultaneous integrated boost radiotherapy/Hippocampus/Cognitive function引用本文复制引用
卢峰,李璐璐,张飞,牛雷雷,李太平..旋转容积调强放疗在脑转移瘤患者全脑+同步推量放疗中对海马区保护及认知功能的影响[J].中国肿瘤外科杂志,2023,15(6):567-571,5.
