中国肿瘤外科杂志2023，Vol.15Issue(6)：599-608,10.DOI:10.3969/j.issn.1674-4136.2023.06.013
融合基因在唾液腺肿瘤中的研究进展
Research progress of fusion genes in salivary gland tumors
摘要
Abstract
Salivary gland tumors are common oral and maxillofacial tumors with heterogeneity.The treatment options for inoperable,recurrent,and metastatic patients of salivary gland tumors are very limited,and the discovery of fusion genes opens up a new way to their diagnosis and treatment.The main targets of fusion genes encoding novel fusion oncoproteins or ectopic expressed normal/truncated oncoproteins are transcriptional coactivators,tyrosine kinase receptors,and transcription factors involved in growth factor signaling and cell cycle regulation,some of which or pathways activated by these targets are targetable.With the further step into the era of precision medicine and targeted therapy,more comprehensive molecular analysis will provide new insights into the diagnosis and molecular pathogenesis of various salivary gland tumors,and provide more treatment options for patients with poor response to conventional treatment.This article reviews the types,functional roles,and targeted drugs of fusion genes in benign and malignant salivary gland tumors,aiming to provide a new direction for the diagnosis,mechanism,and clinical treatment of fusion genes in salivary gland tumors.关键词
唾液腺肿瘤/融合基因/诊断/靶向治疗Key words
Salivary gland tumors/Fusion genes/Diagnosis/Targeted Therapy引用本文复制引用
郑鑫,程帅,姚瑶,张园..融合基因在唾液腺肿瘤中的研究进展[J].中国肿瘤外科杂志,2023,15(6):599-608,10.基金项目
国家自然科学基金(81902780) （81902780）
上海市防癌抗癌事业发展基金会2020探索肿瘤科研基金(HX202003) （HX202003）
