中国癌症防治杂志2023，Vol.15Issue(6)：644-649,6.DOI:10.3969/j.issn.1674-5671.2023.06.08
肝门部胆管癌手术疗效与安全性的影响因素分析
Factors influencing the efficacy and safety of surgery for hilar cholangiocarcinoma
摘要
Abstract
Objective To investigate the risk factors of surgical complications of grade≥Ⅲa and the overall survival rate of hilar cholangiocarcinoma(HC)after resection.Methods The clinical data of 62 patients with HC who underwent surgical resection in the Guangxi Medical University Cancer Hospital from June 2010 to March 2022 were retrospectively analyzed.The risk factors of postoperative complications of grade≥Ⅲa were analyzed by virtue of logistic regression analysis,and cox regression model was used to analyze the factors influencing overall survival.Results The incidence of postoperative complications in HC patients was 73.5%(36/49),among which the incidence of≥Ⅲa complications and the perioperative mortality accounted for 46.9%(23/49)and 10.2%(5/49),respectively.Intraoperative blood loss>500 mL and AJCC stage Ⅲ/Ⅳ were independent risk factors for postoperative complications grade≥Ⅲa in HC patients(all P<0.05).The median survival of HC patients was 24.0 months,and the 1-year,3-year and 5-year overall survival rates were 73%,49%and 20%,respectively.Preoperative CA19-9≥150 U/L and total caudate lobed resection were independent factors affecting the overall survival rate(all P<0.05).Conclusions AJCC stage Ⅲ/Ⅳ and intraoperative blood loss>500 mL are risk factors for perioperative complications≥gradeⅢa after HC resection.Preoperative CA19-9≥150 U/L is a risk factor for postoperative overall survival,and total caudate lobectomy is a protective factor for postoperative overall survival.关键词
肝门部胆管癌/手术切除/并发症/总生存期Key words
Hilar cholangiocarcinoma/Surgical resection/Complication/Overall survival分类
医药卫生引用本文复制引用
杨大龙,陆海明,钟鉴宏,齐鲁楠,陈祖舜,向邦德,黎乐群,马良..肝门部胆管癌手术疗效与安全性的影响因素分析[J].中国癌症防治杂志,2023,15(6):644-649,6.基金项目
国家自然科学基金项目(82260569) （82260569）
广西中医药适宜技术开发与推广项目(GZSY23-66) （GZSY23-66）
