中国医学装备2023，Vol.20Issue(12)：96-100,5.DOI:10.3969/J.ISSN.1672-8270.2023.12.020
超声引导下细针穿刺抽吸活检联合基因检测在甲状腺TI-RADS4级结节诊断中的应用
Application of ultrasound-guided FNAB combined with gene testing in the diagnosis of TI-RADS grade 4 nodule of thyroid
摘要
Abstract
Objective:To explore the diagnostic value of fine needle aspiration cytological biopsy(FNAB)under ultrasound-guided combined with the detection of point mutation of mutant B1 gene of carcinogenic homologue of murine sarcomatous virulent bacteria V600E for grade 4 nodule of thyroid imaging reporting and data system(TI-RADS)of thyroid.Methods:A total of 78 patients with TI-RADS grade 4 nodules who underwent surgery in General Hospital of Huainan Oriental Hospital Group during September 2019 and September 2021 were observed.All patients underwent ultrasound-guided FNAB examination and BRAF V600E gene testing before surgery.The postoperatively pathological results were used as gold standard to analyze the values of ultrasound-guided FNAB examination,BRAF V600E gene testing and the combined diagnosis of them.Results:Postoperatively pathological results showed 60 cases(76.92%)were malignant tumors,and all of which were papillary thyroid carcinoma.The results of Kappa consistency test between ultrasound-guided FNAB examination and pathological control,and between BRAF V600E gene testing and pathological control indicated that the Kappa values of them were respectively 0.430 and 0.583,and the Kappa value of the combined examination of them was 0.720.The sensitivity,specificity,positive predictive value and negative predictive value of the combined examination were respectively 98.33%,66.67%,90.77%and 92.31%in diagnosing thyroid nodule.Conclusion:For TI-RADS grade 4 thyroid nodule,the ultrasound-guided FNAB examination combined with BRAF V600E gene testing can significantly improve the diagnostic value.关键词
甲状腺TI-RADS4级结节/细针穿刺细胞学活检/鼠类肉瘤滤过性毒菌致癌同源体B1基因/基因突变Key words
Grade 4 nodule of thyroid imaging reporting and data system(TI-RADS)/Fine needle aspiration cytological biopsy(FNAB)/Mutant B1 gene of carcinogenic homologue of murine sarcomatous virulent bacteria(BRAF)/Gene mutation分类
医药卫生引用本文复制引用
翟哲,邓大同,孟云,段萍萍,张超学..超声引导下细针穿刺抽吸活检联合基因检测在甲状腺TI-RADS4级结节诊断中的应用[J].中国医学装备,2023,20(12):96-100,5.基金项目
安徽省自然科学基金(1908085MH207)"甲状腺功能减退对妊娠期大鼠下丘脑垂体卵巢轴及生殖功能影响" （1908085MH207）
