中成药2023，Vol.45Issue(12)：3994-3999,6.DOI:10.3969/j.issn.1001-1528.2023.12.023
尖海龙共附生真菌Talaromyces amestolkiae次生代谢产物的研究
Secondary metabolites from symbiotic fungi Talaromyces amestolkiae of Syngnathus acus
摘要
Abstract
AIM To study the secondary metabolites from symbiotic fungi Talaromyces amestolkiae of Syngnathus acus Linnaeus.METHODS The methanol extract from Talaromyces amestolkiae fermentation was isolated and purified by silica gel,Sephadex LH-20,TLC and preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Ten compounds were isolated and identified as 2,4-bis(1,1-dimethylethyl)benzeneethanol(1),aspergillumarins A(2),peniciisocoumarins H(3),2-(2-hydroxypropyl)-5-methyl-7-hydroxychromone(4),6-demethylvermistatin(5),penicimarin B(6),penicimarin C(7),8-hydroxy-6-methoxy-3-methylisocoumarin(8),polygonolide(9),ganoderpurine(10).CONCLUSION Compound 1 is a new natural product.Compounds 3-5,8-10 are isolated from this fungi for the first time.关键词
尖海龙/共附生真菌/Talaromyces amestolkiae/次生代谢产物/分离鉴定Key words
Syngnathus acus Linnaeus/symbiotic fungi/Talaromyces amestolkiae/secondary metabolites/isolation and identification分类
医药卫生引用本文复制引用
雷力荣,金梦莹,郭大乐,邓赟..尖海龙共附生真菌Talaromyces amestolkiae次生代谢产物的研究[J].中成药,2023,45(12):3994-3999,6.基金项目
国家自然科学基金面上项目(81973460) （81973460）
四川省重点研发项目(2021YFN0134) （2021YFN0134）
