中兽医医药杂志2023，Vol.42Issue(6)：32-37,封3,7.DOI:10.13823/j.cnki.jtcvm.2023.110
基于网络药理学探究鱼腥草桔蓝口服液对家禽呼吸道疾病的作用机制
Exploring the action mechanism of Yuxingcao Jielan oral liquid on the respiratory diseases in poultry based on network pharmacology
摘要
Abstract
To investigate the action mechanism of Yuxingcao Jielan oral liquid on the treatment of respiratory diseases in poultry.In this study,the chemical composition and action targets of Yuxingcao Jielan oral liquid were searched,a drug-target network map and an intersecting target protein(PPI)interaction network map were constructed.The enrichment of intersecting targets was analyzed.The molecular docking validation of drug active ingredients and core targets were analyzed by molecular docking technology.The results showed that Yuxingcao Jielan oral liquid,in the presence of active ingredients such as quercetin,kaempferol and β-sitosterol,affected key targets such as interleukin-6(IL-6),B-cell lymphoma-2(BCL2),signal transducer and activator of transcription 3(STAT3).GO functional enrichment yielded 58 biological process entries,4 cellular composition entries,and 15 molecular function entries.KEGG pathway analysis revealed that the intersectinggenes mainly acted on multiple signaling pathways such as C-type lectin receptor signaling pathway,FoxO signaling pathway,MAPK signaling pathway and VEGF signaling pathway to treat poultry respiratory diseases.The molecular docking results indicated good binding of the key components of the drug to the core protein target.The results indicated that Yuxingcao Jielan oral liquid could treat poultry respiratory diseases through a multi-component,multi-target and multi-pathway mechanism.关键词
鱼腥草桔蓝口服液/家禽/呼吸道疾病/网络药理学/分子对接Key words
Yuxingcao Jielan oral liquid/poultry/respiratory disease/network pharmacology/molecular docking分类
农业科技引用本文复制引用
荣轩,房思远,赵子玉,朱永明,李育明,赵兵令..基于网络药理学探究鱼腥草桔蓝口服液对家禽呼吸道疾病的作用机制[J].中兽医医药杂志,2023,42(6):32-37,封3,7.基金项目
农业科技成果转化资金项目(202360102020001) （202360102020001）
石家庄市禽用中药产业技术研究院(238790749A) （238790749A）
河北省中兽药产业技术研究院建设补助经费(225790267H) （225790267H）
河北省功能性饲料添加剂技术创新中心建设补助经费(217790537H) （217790537H）
