miR-29a影响eNOS蛋白表达参与血管内皮障碍机制研究OA
Mechanism of miR-29a affecting eNOS protein expression and participating in vascular endothelial dysfunction
目的 探究 miR-29a 抑制血管内皮细胞体外血管生成谷氨酰胺酶靶向细胞,初步寻求炎症因子诱发血管内皮功能障碍的相关机制.方法 选择人脐静脉内皮细胞作为研究细胞系,分别使用重组人肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、血清淀粉样蛋白A(serum amyloid A,SAA)对细胞系进行干预,采用实时荧光定量聚合酶链反应(real-time fluorescence quantitative polyme…查看全部>>
Objective To explore the inhibitory effect of miR-29a on in vitro angiogenesis of vascular endothelial cells by targeting cells with glutaminase,and preliminarily explore the relevant mechanisms of inflammatory factors inducing vascular endothelial dysfunction.Methods Human umbilical vein endothelial cells were selected as research cell lines,and the cell lines were intervened by recombinant human tumor necrosis factor-α(TNF-α)and serum amyloid A(SAA)respect…查看全部>>
邹鹏涛;何磊;张方;朱波
南昌大学第二附属医院心血管内科,江西南昌 330006南昌大学第二附属医院心血管内科,江西南昌 330006南昌大学第二附属医院心血管内科,江西南昌 330006南昌大学第二附属医院心血管内科,江西南昌 330006
临床医学
炎症因子肿瘤坏死因子-α血清淀粉样蛋白AmiR-29a内皮型一氧化氮合酶
Inflammatory factorsTumor necrosis factor-αSerum amyloid protein AmiR-29aEndothelial nitric oxide synthase
《中国现代医生》 2023 (36)
1-4,67,5
江西省卫生计生委科技计划项目(20195199)
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