中医药信息2023，Vol.40Issue(12)：42-46,5.DOI:10.19656/j.cnki.1002-2406.20231208
基于脑肠轴理论探讨针刺治疗帕金森病认知障碍的机制
Mechanism of Acupuncture Treatment of Cognitive Impairment in Parkinson's Disease Based on the Theory of Brain-Gut Axis
摘要
Abstract
The brain-gut axis,as an information channel between the brain and the gastrointestinal tract,is closely related to Parkinson's disease cognitive impairment(PDCI).Acupuncture can improve PDCI in clinical practice,but its mechanism of action has not been fully clarified.In this paper,by summarizing the function of the brain-gut axis,the risk factors and pathogenesis of PDCI,and the influence of the brain-gut axis on cognition and so on,we explore how acupuncture regulates the abundance of gut microbiota and levels of brain gut peptides,balances the hormone release of the hypothalamic pituitary adrenal axis(HPA),inhibits inflammatory responses,and protects nerves,thereby improving PDCI.关键词
脑肠轴/针刺/帕金森病/认知障碍Key words
Brain-gut axis/Acupuncture/Parkinson's disease/Cognitive impairment引用本文复制引用
朱婉怡,黄金玉,梁杏杏,王龙,刘智斌..基于脑肠轴理论探讨针刺治疗帕金森病认知障碍的机制[J].中医药信息,2023,40(12):42-46,5.基金项目
国家自然科学基金项目(81873388) （81873388）
