组织工程与重建外科杂志2023，Vol.19Issue(6)：544-548,5.DOI:10.3969/j.issn.1673-0364.2023.06.005
难治性瘢痕疙瘩术后电子线放射治疗疗效分析及患者满意度研究
Efficacy analysis and patient satisfaction study of postoperative electron beam radiotherapy for refractory keloid
摘要
Abstract
Objective To explore the therapeutic effect of postoperative electron beam radiotherapy for intractable keloid and the influencing factors of recurrence,and to evaluate patients'satisfaction with the therapeutic effect.Methods From 2019 to 2021,37 patients with refractory keloids,including 40 keloids,were treated with electron beam irradiation after operation.The radiotherapy was conducted with 6-9 MeV electron beam irradiation from the skin,and the irradiation dose was 20 Gy/5 Gy/4 F.The general clinical data of patients were collected and followed up regularly after operation.After the observation,questionnaires were distributed to all patients to evaluate their satisfaction.The treatment effect and adverse reactions of patients were analyzed,and the factors affecting recurrence were analyzed by Logistic regression.Results Among the 40 scars,4 cases(10%)recurred after treatment,and 5 cases(12.5%)had no obvious change after treatment,and the effective rate was 77.5%.The main adverse reactions were skin pigmentation and incision expansion.Univariate analysis showed that sex,past history,time interval from operation to radiotherapy,continuous irradiation and plasma fibrinogen content were related to recurrence.Multivariate analysis showed that the interval between operation and radiotherapy for more than 24 hours was an independent risk factor for recurrence,and continuous irradiation was an independent protective factor.Recurrence,incision expansion and pigmentation were the main reasons for patients'dissatisfaction.Conclusion Surgery combined with electron beam radiotherapy is an effective method for the treatment of refractory keloid.The time from operation to radiotherapy and continuous irradiation are independent prognostic factors affecting the recurrence of keloid,and the subjective evaluation of patients is not completely consistent with their clinical manifestations and examinations.关键词
瘢痕疙瘩/电子线照射/复发/疗效Key words
Keloid/Electron beam irradiation/Recurrence/Curative effect分类
医药卫生引用本文复制引用
赵敏,李丽,赵瑞东,马婷婷,程剑..难治性瘢痕疙瘩术后电子线放射治疗疗效分析及患者满意度研究[J].组织工程与重建外科杂志,2023,19(6):544-548,5.基金项目
第四师可克达拉市科技计划项目(2022SF14). （2022SF14）
