组织工程与重建外科杂志2023，Vol.19Issue(6)：597-601,5.DOI:10.3969/j.issn.1673-0364.2023.06.015
抑制细胞衰老在骨关节炎软骨再生治疗中的研究进展
Research progress of inhibiting cell aging in the treatment of cartilage regeneration in osteoarthritis
摘要
Abstract
In recent years,the role of cellular aging in the occurrence and development of osteoarthritis has become a research hotspot.The existing evidence has basically confirmed that abnormal cartilage repair and the occurrence and development of osteoarthritis(OA)have a causal relationship with chondrocyte aging and mesenchymal cells(MSCs)aging.Targeted elimination of aging cells and promotion of the rejuvenation of stem cells can effectively delay OA.In this paper,the pathological role of cellular aging in the occurrence and development of OA and potential therapeutic targets were reviewed.Cell senescence is an important biological phenomenon and potential therapeutic target in the occurrence and development of OA.Further study of its biological mechanism is helpful for the early prevention and treatment of OA.关键词
骨关节炎/细胞衰老/软骨细胞/干细胞Key words
Osteoarthritis/Cellular senescence/Chondrocytes/Stem cells分类
医药卫生引用本文复制引用
叶启程,聂萍..抑制细胞衰老在骨关节炎软骨再生治疗中的研究进展[J].组织工程与重建外科杂志,2023,19(6):597-601,5.基金项目
国家自然科学基金(32101094). （32101094）
