成都大学学报（自然科学版）2023，Vol.42Issue(4)：342-347,6.DOI:10.3969/j.issn.1004-5422.2023.04.002
奥拉帕利不同晶型的制备、表征与稳定性研究
Preparation,Characterization and Stability of Different Crystal Forms of Olaparib
摘要
Abstract
Six crystal forms of olaparib were prepared and their relative stability was studied.First of all,the forms were characterized by X-ray powder diffraction,thermal analysis,attenuated total refraction in-frared spectroscopy and Raman spectroscopy.Then,their relative stability was determined through high-temperature phase transformation and solvent-mediated transformation.Among these Six crystal forms,Form H is a hydrate,Form A and L are anhydrous,and the other three crystals are heteromorphic sol-vates.Also,there are obvious differences in the infrared spectroscopy data between the six solid forms,which can be used for the identification or polymorph control in the production process.There exist obvi-ous differences in X-ray powder diffraction,thermal analysis or Raman spectorscopy in A,H and L.Fur-thermore,Form A,L and H can also be identified and controlled by X-ray powder diffraction,thermal a-nalysis or Raman spectroscopy.In addition,the stability relationship is Form A＞Form L for solvent-free Forms,that is to say,Form A is the most thermodynamic stable form.关键词
奥拉帕利/多晶型/异质同晶溶剂化物/稳定性Key words
olaparib/polymorph/isomorphism solvate/stability分类
化学化工引用本文复制引用
李宏名,胡瑞馨,郑维江,张娇..奥拉帕利不同晶型的制备、表征与稳定性研究[J].成都大学学报（自然科学版）,2023,42(4):342-347,6.基金项目
国家"重大新药创制"科技重大专项资助项目(2012ZX092021-013) （2012ZX092021-013）
成都市高新区重点科技创新计划资助项目(15DFZD023) （15DFZD023）
