口腔疾病防治2024，Vol.32Issue(1)：76-80,5.DOI:10.12016/j.issn.2096-1456.2024.01.012
牙周膜干细胞免疫调节特性的研究进展
Research progress on immunomodulatory properties of periodontal ligament stem cells
摘要
Abstract
Periodontal ligament stem cells(PDLSCs)have the potential for multidirectional differentiation and are the preferred seed cells for periodontal tissue regeneration.In recent years,a large number of studies have confirmed that PDLSCs also possess broad immunomodulatory properties.Therefore,in-depth exploration of their specific molecular mechanisms is of great significance for the treatment of periodontitis.The aim of this paper is to summarize the research progress on the regulation of PDLSCs on various immune cells and the effect of the inflammatory environment on the im-mune characteristics of PDLSCs to provide an important theoretical basis for the allotransplantation of PDLSCs and im-prove the therapeutic effect of periodontal tissue regeneration.Studies have shown that PDLSCs possess a certain degree of immunosuppressive effect on both innate and acquired immune cells,and inflammatory stimulation may lead to the im-pairment of the immunoregulatory properties of PDLSCs.However,current studies are mainly limited to in vitro cell tests and lack in-depth studies on the immunomodulatory effects of PDLSCs in vivo.In vivo studies based on cell lineage trac-ing and conditional gene knockout technology may become the main directions for future research.关键词
牙周膜干细胞/组织再生/免疫调节/获得性免疫/固有免疫/中性粒细胞/间充质干细胞/炎症Key words
periodontal ligament stem cells/tissue regeneration/immunomodulatory properties/acquired immu-nity/innate immunity/neutrophile granulocyte/mesenchymal stem cells/inflammation分类
医药卫生引用本文复制引用
文雯,田宇阳,谢旭东..牙周膜干细胞免疫调节特性的研究进展[J].口腔疾病防治,2024,32(1):76-80,5.基金项目
国家自然科学青年基金项目(82201073) （82201073）
四川省自然科学基金面上项目(2022NSFSC0795)This study was supported by the grants from National Natural Science Foundation of China(No.82201073) （2022NSFSC0795）
Natural Sci-ence Foundation of Sichuan Province(No.2022NSFSC0795). （No.2022NSFSC0795）
