口腔疾病防治2024，Vol.32Issue(2)：131-136,6.DOI:10.12016/j.issn.2096-1456.2024.02.007
光动力治疗右颊黏膜疣状癌1例报道及文献回顾
Photodynamic therapy in the treatment of the right buccal mucosa verrucous carcinoma:a case report and lit-erature review
摘要
Abstract
Objective To explore the photodynamic treatment method and therapeutic effect of oral verrucous carci-noma and to provide a reference for the clinic.Methods This study follows the requirements of medical ethics.This paper summarized the photodynamic treatment of an oral verrucous carcinoma with a diameter of approximately 2.5 cm in the right buccal mucosa and retrospectively analyzed the characteristics and treatment of oral verrucous carcinoma and the photodynamic treatment of potential malignant lesions of the oral mucosa through a review of the literature.Results After four rounds of photodynamic therapy,the size of the right buccal lesion was significantly reduced.After 6 months of follow-up,the white verrucous hyperplasia of the right buccal mucosa had completely subsided,and there was no obvious scar formation.Three years after treatment,there was no recurrence of the lesion in the right buccal mu-cosa and no obvious scar formation in the treated area.The degree of mouth opening was 3 fingers,and there was no lymph node enlargement in the bilateral submandibular,submental or neck.The literature review shows that oral verru-cous carcinoma is a rare subtype of squamous cell carcinoma with the characteristics and biological behaviors of slow growth,low malignancy,and rare metastasis.Surgery is the preferred treatment,but there are some limitations.Photody-namic therapy is a minimally invasive,repeatable treatment with mild adverse reactions.In recent years,photodynamic therapy has been gradually applied for the treatment of potential malignant disorders of the oral mucosa and early oral squamous cell carcinoma and has achieved positive results,but it has not been reported for the treatment of oral verru-cous cancer.Conclusion Photodynamic therapy is a new option for nonsurgical resection of oral verrucous carcinoma.关键词
光动力疗法/口腔疣状癌/口腔鳞状细胞癌/口腔黏膜潜在恶性疾患/疣状增生/颊黏膜/光敏剂/光生物学反应Key words
photodynamic therapy/oral verrucous carcinoma/oral squamous cell carcinoma/oral potentially malignant disorders/verrucous hyperplasia/buccal mucosa/photosensitizer/photobiological reaction分类
医药卫生引用本文复制引用
吕世萍,杨璐,金鑫..光动力治疗右颊黏膜疣状癌1例报道及文献回顾[J].口腔疾病防治,2024,32(2):131-136,6.基金项目
国家自然科学基金面上项目(81870775) （81870775）
重庆市自然科学基金面上项目(CSTB2022NSCQ-MSX1148)This study was supported by the grants from National Natural Science Foundation of China(No.81870775) （CSTB2022NSCQ-MSX1148）
General Pro-gram of Chongqing Municipal Natural Science Foundation(No.CSTB2022NSCQ-MSX1148). （No.CSTB2022NSCQ-MSX1148）
