口腔疾病防治2024，Vol.32Issue(2)：143-148,6.DOI:10.12016/j.issn.2096-1456.2024.02.009
m5C甲基化修饰及其在肿瘤免疫治疗中的研究进展
Research progress on m5C methylation and its prospects in tumor immunotherapy
摘要
Abstract
Epigenetic modification plays an important role in the biological regulatory process of eukaryotic cells.Tumor immunotherapy is an important means and clinical strategy for the treatment of some cancers.5-Methylcytosine(m5C)is an important component of the epigenetic regulatory network discovered after m6A and has become a new topic for life science research in recent years.The m5C methylation of RNA can affect the fate of the modified RNA mole-cules and play an important role in various biological processes,including RNA stability,protein synthesis and tran-scriptional regulation.Recent studies have shown that m5C writers,erasers and readers are related to a variety of cellu-lar biological processes and systemic diseases,including the occurrence,metastasis and tumor immune microenviron-ment.m5C methylation can widely affect gene expression and the biological process of tumorigenesis and development at multiple levels,but its specific mechanism and potential interaction with other epigenetic modifications in tumor im-munotherapy are still unclear,and its regulatory mechanism,risk assessment and role in targeted therapy for malignant tumors need to be further studied.This article will review the dynamic regulatory network of m5C,the biological role of m5C modification in solid tumors and potential targets in tumor immunotherapy.关键词
肿瘤/表观遗传修饰/甲基化修饰/5-甲基胞嘧啶/N6甲基腺苷/RNA甲基化/免疫治疗/肿瘤微环境/m5C调节蛋白Key words
tumor/epigenetics/methylation/5-methylcytosine/N6-methyladenosine/RNA methylation/immunotherapy/tumor microenvironment/m5C regulatory protein分类
医药卫生引用本文复制引用
陆云洋,杜维东,余东升..m5C甲基化修饰及其在肿瘤免疫治疗中的研究进展[J].口腔疾病防治,2024,32(2):143-148,6.基金项目
国家自然科学基金项目(82073378) （82073378）
广东省自然科学基金(2021A1515012399)This study was supported by National Natural Science Foundation of China(No.82073378)and Natural Science Foun-dation of Guangdong Province(No.2021A1515012399). （2021A1515012399）
