国际医药卫生导报2023，Vol.29Issue(24)：3625-3628,4.DOI:10.3760/cma.j.issn.1007-1245.2023.24.020
瑞马唑仑联合阿芬太尼在老年患者无痛胃肠镜检查中的应用效果
Effect applying remazolam in painless gastroenteroscopy in elderly patients
摘要
Abstract
Objective To investigate the effect of remazolam on cognitive function and hemodynamics in elderly patients undergoing painless gastroenteroscopy.Methods One hundred and two elderly patients undergoing painless gastroenteroscopy at Shouguang Hospital of Traditional Chinese Medicine from January 2021 to December 2022 were selected for the randomized controlled trial,and were divided into an observation group and a routine group by the random number table method,with 51 cases in each group.There were 31 males and 20 females in the observation group;they were(9.63±6.25)years old.There were 20 males and 31 females in the routine group;they were(79.06±6.93)years old.The observation group took tsyloremazolam and afentanil for anesthesia,and the routine group took propofol and afentanil for anesthesia.The times to come to and times to leave the room,the scores of Mini-Mental State Examination before and 2 and 5 d after the operation,and the blood pressures and oxygen saturations before(T1)and 3(T2),6(T3),and 9 min(T4)after administration were compared between the two groups.t and x2 tests were applied.Results The time to come to and the time to leave the room in the observation group were shorter than those in the routine group[(7.25±1.1 5)min vs.(9.69±1.68)min and(28.74±4.25)min vs.(37.85±6.23)min],with statistical differences(t=14.195 and 7.852;both P＜0.05).There were statistical differences in the scores of MMSE of group,time,and interaction between the two groups(Fbetween groups=17.358;Ftime=19.652;Finteraction=13.745;all P＜0.05).The scores of MMSE 2 and 5 d after the operation in the observation group were higher than those in the routine group.The systolic and diastolic blood pressures and oxygen saturation at T2 in the observation group were higher than those in the routine group(Fbetween groups=9.580,9.541,and 19.520;all P＜0.05).The systolic and diastolic blood pressures and oxygen saturation at T3 and T4 were higher than those at T2 in the routine group(F时间=8.852,9.580,and 8.520;all P＜0.05).Conclusion Applying remazolam in painless gastroenteroscopy in elderly patients can shorten their time to come to,improve their cognitive function,and reduce the impact on their hemodynamics,which is worthy of clinical application.关键词
瑞马唑仑/阿芬太尼/无痛胃肠镜检查/认知功能/血液动力学/老年患者Key words
Remazolam/Alfentanil/Painless gastroenteroscopy examination/Cognitive function/Hemodynamics/Elderly patients引用本文复制引用
宋志永,张晓华,李泉,王昭安,任高燕..瑞马唑仑联合阿芬太尼在老年患者无痛胃肠镜检查中的应用效果[J].国际医药卫生导报,2023,29(24):3625-3628,4.基金项目
山东省医药卫生科技发展计划项目(2019WS580)Project of Plan of Developmental Plan of Medical and Health Science and Technology in Shandong(2019WS580) （2019WS580）
