广州医药2023，Vol.54Issue(12)：72-77,6.DOI:10.3969/j.issn.1000-8535.2023.12.012
监测外周血CD34+细胞计数预测普乐沙福联合G-CSF自体干细胞动员的效果
Predictive effect of monitoring peripheral blood CD34+ cell count on autologous stem cell mobilization with plerixafor
摘要
Abstract
Objective To explore the predictive value of peripheral blood CD34+ cell count for the stem cell mobilization effect of plerixafor.Methods The clinical data of 13 patients who used granulocyte colony-stimulating factor + plerixafor for stem cell mobilization in the Seventh Affiliated Hospital of Sun Yat-sen University from May 2021 to July 2023 were retrospectively analyzed.The changes of peripheral blood CD34+ cell count in all patients before and after the mobilization of plerixafor were analyzed.Results In 13 enrolled patients,there were 10 lymphoma patients and 3 multiple myeloma(MM)patients.One patient was newly diagnosed with MM,and the other two were recurrent patients.The lymphoma cases included 3 mantle cell lymphoma,6 diffuse large B cell lymphoma and 1 B cell non-Hodgkin's lymphoma(type cannot be specified).The CD34+ cell counts were increased in all patients when mobilized with granulocyte colony-stimulating factor before plerixafor.The CD34+ cell count was 13.3(2.5～76.1)/μL and 73.6(10.4～208.70)/μL before and after the use of plerixafor,between which the difference was statistically significant(Z=0.578,P＜0.05),and the median increased of 4.18(1.99～13.6)times.There were 2 patients failed in mobilizing whose CD34+ cell count was less than 5/μL before using plerixafor.Spearman analysis showed that there was a positive correlation in peripheral blood CD34+ cell count before and after the use of plerixafor(rs=0.80,P=0.032).The CD34+ cell count after using plerixafor was a good predictor of the collection results(P=0.002).Conclusions Monitoring the CD34+ cell count in peripheral blood has a certain predictive value for the stem cell mobilization effect of plerixafor.The higher of CD34+ cell count after the use of plerixafor,the higher of CD34+ collection.关键词
造血干细胞/动员/普乐沙福/CD34+细胞计数Key words
hematopoietic stem cell/mobilization/plerixafor/CD34+ cell count引用本文复制引用
刘芳洁,宾婷,谢媚,解荣丽,王小博..监测外周血CD34+细胞计数预测普乐沙福联合G-CSF自体干细胞动员的效果[J].广州医药,2023,54(12):72-77,6.基金项目
广东省自然科学基金联合基金-青年项目(2019A151510703) （2019A151510703）
