赣南医学院学报2023，Vol.43Issue(11)：1102-1106,1141,6.DOI:10.3969/j.issn.1001-5779.2023.11.002
贵州14486例儿童血清25-羟基维生素D水平分析
Analysis of serum 25-hydroxyvitamin D levels in 14 486 children in Guizhou
摘要
Abstract
Objective:To understand the levels of 25-hydroxyvitamin D[(25-(OH)D)]and the nutritional status of vitamin D in children aged 0-18 years old in Guizhou,and to provide the basis for the scientific prevention and treatment of vitamin D deficiency.Methods:Healthy children aged 0-18 who received routine physical examination at Guizhou Provincial People's Hospital in 2019 were selected.Chemiluminescence microparticle immunoassay was used to detect serum 25-(OH)D levels,and the differences in 25-(OH)D level and vitamin D nutritional status were compared among different genders,ages and seasons.Results:The mean serum 25-(OH)D concentration of 14 486 children was(22.80±9.94)μg·L-1,and 79.22%of the children's 25-(OH)D was lower than the ideal level.There was no significant difference in 25-(OH)D levels in different gender groups(P＞0.05),but the nutritional status of vitamin D was significantly different between different genders,the prevalence of vitamin D deficiency in girls was significantly higher than that in boys(P＜0.001);There was a statistically significant difference in 25-(OH)D levels and vitamin D nutritional status among different age groups(P＜0.001).The serum 25-(OH)D concentration decreased gradually with the increase of age,the level of 25-(OH)D was significantly lower in children over 3 years old,while the rate of vitamin D deficiency was significantly increased;25-(OH)D levels and vitamin D nutritional status were significantly different in different seasons(P＜0.001),25-(OH)D level was higher in summer and autumn,and the prevalence of vitamin D deficiency and deficiency was lower.Children had lower levels of 25-(OH)D and higher prevalence of vitamin D deficiency in spring and winter.Results from other characteristic groups showed that low serum 25-(OH)D levels in children from rural population,the maternal education below high school,children who were exclusively breastfed,and children who took vitamin D preparations irregularly were associated with an increased risk of vitamin D deficiency(P＜0.05).Conclusion:The level of 25-(OH)D in children aged 0-18 years in Guizhou is seriously lower than the ideal level,and vitamin D deficiency is obvious,the older the age,the more serious the vitamin D deficiency.Vitamin D level was correlated with age,sex,season,urban and rural household registration,maternal education,feeding mode and whether to take vitamin D preparation irregularly,but not with maternal age and residential area.At the same time,emphasis should be placed on the supplementation of vitamin D in children over 3 years old,and also the supplementation in spring and winter.关键词
儿童/25-羟基维生素D/营养状况/佝偻病Key words
Children/25-hydroxyvitamin D/Nutritional status/Rickets分类
医药卫生引用本文复制引用
任家谋,张春梅,刘娜,冯胜,井沆..贵州14486例儿童血清25-羟基维生素D水平分析[J].赣南医学院学报,2023,43(11):1102-1106,1141,6.基金项目
贵州省卫生健康委员会科学技术基金项目(GZWKJ2023-452) （GZWKJ2023-452）
贵州省人民医院青年基金项目(GZSYQN201708) （GZSYQN201708）
