国际医药卫生导报2023，Vol.29Issue(23)：3366-3369,4.DOI:10.3760/cma.j.issn.1007-1245.2023.23.010
精准医学指导在ASO介入术后运动康复中的应用研究
Application of precision medicine guidance in exercise rehabilitation after ASO intervention
摘要
Abstract
Objective To observe the effect of exercise rehabilitation training under the guidance of precision medicine on the vascular endothelial function and prognosis in patients after intervention of arteriosclerosis obliterans(ASO).Methods This was a prospective cohort study.A total of 123 ASO patients admitted to Nanyang First People's Hospital from January 2020 to March 2022 were selected as the study objects,and were divided into a routine group(61 cases)and a rehabilitation group(62 cases)by the random number table method.In the routine group,there were 33 males and 28 females,aged 45-75(61.36±5.25)years.In the rehabilitation group,there were 32 males and 30 females,aged 43-77(60.45±5.13)years.Routine rehabilitation exercise was performed in the routine group,and exercise rehabilitation training based on precision medicine was performed in the rehabilitation group.The enrolled patients were followed up for one year to compare their self-management ability,vascular endothelial function,and occurrence of related complications.t test and x2 test were used.Results After intervention,the scores of Exercise of Self-care Agency Scale(ESCA)and General Self-Efficacy Scale(GSES)in the rehabilitation group[(125.44±20.61)points and(2.66±0.25)points]were higher than those in the routine group[(110.33±20.47)points and(1.92±0.61)points],with statistically significant differences(t=4.079 and 8.829,both P＜0.001).At the end of follow-up,the flow mediated vasodilation(FMD)and nitroglycerin mediated vasodilation(NMD)[(12.25±3.14)％and(9.85±2.41)％]in the rehabilitation group were higher than those in the routine group[(10.11±3.47)％and(8.22±2.16)％],while the pulse wave velocity(PWV)[(10.24±3.45)m/s]was lower than that in the routine group[(12.41± 3.12)m/s],with statistically significant differences(t=3.588,3.948,and 3.657,all P＜0.001).At the end of follow-up,the incidence of related complications in the rehabilitation group was 6.45％(4/62),which was lower than that in the routine group[18.03％(11/61)],with a statistically significant difference(x2=6.242,P＜0.05).Conclusions The guidance of precision medicine can effectively improve the health cognition level in patients after ASO intervention and enhance their self-management ability.The exercise rehabilitation training based on precision medicine can promote the recovery of vascular endothelial function,and has a positive role in reducing the risk of related complications.关键词
动脉硬化闭塞症/精准医学/运动康复训练/血管内皮功能/预后Key words
Arteriosclerosis obliterans/Precision medicine/Exercise rehabilitation training/Vascular endothelial function/Prognosis引用本文复制引用
郎征,王喆,姚小军..精准医学指导在ASO介入术后运动康复中的应用研究[J].国际医药卫生导报,2023,29(23):3366-3369,4.基金项目
河南省医学科技攻关项目(LHGJ202101128)Medical Science and Technology Research Project of Henan Province(LHGJ202101128) （LHGJ202101128）
