广西医科大学学报2023，Vol.40Issue(12)：2057-2063,7.DOI:10.16190/j.cnki.45-1211/r.2023.12.019
联合检测BT、D-LC、LDH对急性肠梗阻患者肠穿孔的预测研究
The predictive study of combined detection of BT,D-LC,and LDH on intestinal perforation in patients with acute intestinal obstruction
摘要
Abstract
Objective:To study the predictive value of combined detection of bacterial endotoxins(BT),D-lactic acid(D-LC),and lactate dehydrogenase(LDH)for intestinal perforation in patients with acute intestinal obstruc-tion.Methods:A total of 106 patients with acute intestinal obstruction admitted to Hebei Chest Hospital from Au-gust 2021 to August 2023 were selected for retrospective study,including 31 patients with intestinal perforation(intestinal perforation group)and 75 patients without intestinal perforation(non-intestinal perforation group).Clinical data and BT,D-LC,LDH at baseline,after 6 h,12 h and 24 h were compared between the two groups,re-ceiver operating characteristic(ROC)curve was used to analyze the predictive value of BT,D-LC and LDH for intestinal perforation.Results:The proportion of patients with severe intestinal duct injury in the intestinal perfo-ration group(100%)was higher than that the in non-perforation group(12.00%)(P＜0.05).After 6 h,BT,D-LC and LDH in both groups showed an increasing trend.After 12 h,BT,D-LC and LDH began to decrease in the non-intestinal perforation,while they still showed an increasing trend in the intestinal perforation group,and BT,D-LC and LDH showed a decreasing trend after 24 h(P＜0.05).BT,D-LC and LDH in the intestinal perforation group were higher than those in the non-intestinal perforation group at baseline,after 6 h,12 h and 24 h(P＜0.05).ROC analysis showed that the AUC of BT,D-LC and LDH in predicting intestinal perforation showed an increasing trend at baseline,after 6 h and after 12 h,and the AUC of BT,D-LC and LDH in predicting in-testinal perforation was the highest after 12 h.After 12 h,the AUC of intestinal perforation predicted by BT and D-LC combined with LDH was 0.935(95%CI:0.870-0.974),the cut-off value was 0.125,the sensitivity was 90.32%,and the specificity was 85.33%(P＜0.05).Conclusion:BT,D-LC and LDH are correlated with intestinal perforation in patients with acute intestinal ob-struction,and patients with intestinal perforation have higher peak value of various indicators,longer duration and lower delay.Combined detection of the three indicators may be a predictive scheme for intestinal perforation to provide decision support for clinical diagnosis and treatment.关键词
细菌内毒素/D-乳酸/乳酸脱氢酶/急性肠梗阻/肠管损伤程度/肠穿孔/预测效能Key words
bacterial endotoxins/D-lactic acid/lactate dehydrogenase/acute intestinal obstruction/the degree of intestinal duct injury/intestinal perforation/predictive efficacy分类
医药卫生引用本文复制引用
王文帅,贾立茹,孙满胜,王倩,王晓阳..联合检测BT、D-LC、LDH对急性肠梗阻患者肠穿孔的预测研究[J].广西医科大学学报,2023,40(12):2057-2063,7.基金项目
2021年度河北省医学科学研究课题计划项目资助(No.20211282) （No.20211282）
