广西医科大学学报2023，Vol.40Issue(12)：2071-2077,7.DOI:10.16190/j.cnki.45-1211/r.2023.12.021
高频超声测量参数与早期类风湿关节炎抗风湿疗效的相关性及预测价值分析
Correlation and predictive value of HFUS measurement parameters and anti-rheumatic effi-cacy of early rheumatoid arthritis
摘要
Abstract
Objective:To explore the correlation between high frequency ultrasound(HFUS)measurement pa-rameters and the anti-rheumatic efficacy of early rheumatoid arthritis(RA),and the value of predicting the effica-cy.Methods:A total of 97 cases of early RA patients admitted to Tongcheng People's Hospital of Anhui Prov-ince from March 2022 to March 2023 were selected as the study group,and another 97 cases of non-RA patients with at least one manifestation of arthritis in the same period were selected as the control group.The HFUS mea-surement parameters(synovial thickness,joint effusion,blood flow signal,bone erosion score),rheumatoid factor(RF),erythrocyte sedimentation rate(ESR),and C-reactive protein(CRP)levels were compared between the two groups.The correlation between HFUS measurement parameter score and ESR,RF,and CRP levels was ana-lyzed.The study group was given anti-rheumatic treatment.The HFUS measurement parameter scores and chang-es of patients with different curative effects before treatment and after 3 months of treatment were compared,the correlation between the changes of HFUS measurement parameter score before and after treatment and the anti-rheumatic efficacy was analyzed,and the value of HFUS measurement parameter score before treatment in pre-dicting the anti-rheumatic efficacy was analyzed.Re-sults:The blood flow signal,synovial thickness,bone erosion,joint effusion score,ESR and serum RF,CRP levels in the study group were higher than those in the control group(P＜0.05);in the study group,the blood flow signal,synovial thickness,bone erosion and joint effusion scores were positively correlated with RF,ESR and CRP levels(P＜0.05);the synovial thickness,blood flow signal,joint effusion and bone erosion scores of patients with good curative effect before treatment and 3 months after treatment were lower than those of pa-tients with poor curative effect,and the changes of each parameter score were greater than those of patients with poor curative effect(P＜0.05);the AUC of anterior synovial thickness,blood flow signal,joint effusion and bone erosion score in predicting anti-rheumatic efficacy were 0.771,0.742,0.735 and 0.741,respectively,which had a certain predictive efficiency,and the AUC of combined prediction of each score was 0.921,which was greater than that of single prediction(z=2.316,2.220,2.887,2.414,P=0.021,0.026,0.004,0.016).Conclusion:HFUS measurement parameters can be used in the early diagnosis of RA and provide reference for early clinical evalua-tion of RA activity and anti-rheumatic efficacy,so as to carry out targeted follow-up intervention and improve prognosis.关键词
高频超声/类风湿关节炎/疾病活动度/诊断价值Key words
high-frequency ultrasound/rheumatoid arthritis/disease activity/diagnostic value分类
医药卫生引用本文复制引用
刘成凤,徐燕,都旭东..高频超声测量参数与早期类风湿关节炎抗风湿疗效的相关性及预测价值分析[J].广西医科大学学报,2023,40(12):2071-2077,7.基金项目
2019年度蚌埠医学院科研项目资助(No.BYKY2019115ZD) （No.BYKY2019115ZD）
