国际医药卫生导报2023，Vol.29Issue(23)：3443-3447,5.DOI:10.3760/cma.j.issn.1007-1245.2023.23.027
布地奈德联合异丙托溴铵雾化治疗小儿支气管肺炎的疗效分析
Therapeutic effect of aerosol inhalation of budesonide combined with ipratropium bromide in the treatment of children with bronchopneumonia
摘要
Abstract
Objective To investigate the efficacy of aerosol inhalation of budesonide combined with ipratropium bromide in the treatment of children with bronchopneumonia and its effects on the levels of serum interleukin(IL)-6 and IL-17A.Methods It was a randomized controlled trial.A total of 106 children with bronchopneumonia admitted to Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University from January 2022 to May 2023 were prospectively selected as the research subjects and were divided into two groups with 53 cases in each group by the sealed envelope method.In the control group,29 males and 24 females,aged(5.23±1.16)years,were given budesonide aerosol inhalation therapy.In the observation group,28 males and 25 females,aged(5.28±1.21)years,were given aerosol inhalation of budesonide+ipratropium bromide.The two groups were compared from the aspects of efficacy,disappearance time of clinical symptoms and signs,changes in immune function,changes in serum inflammatory factor levels,changes in serum procalcitonin(PCT)levels,and drug safety.Independent sample ttest,paired ttest,and x2 test were used.Results The total effective rate of the observation group was higher than that of the control group[96.23％(51/53)vs.79.25％(42/53)](x2=7.102,P=0.008).The disappearance time of cough,shortness of breath,pulmonary rales,fever,and chest film shadow in the observation group were shorter than those in the control group(t=17.453,8.190,10.529,10.266,and 15.488,all P＜0.001).After treatment,the levels of T lymphocyte subsets(CD3+,CD4+,and CD8+),inflammatory factors,and PCT in the two groups were significantly different from those before treatment(all P＜0.05);the levels of CD3+and CD4+in the observation group were higher than those in the control group,and the level of CD8+was lower than that in the control group,with statistically significant differences(t=4.614,7.970,and 9.020,all P＜0.001);the levels of inflammatory factors in the observation group were lower than those in the control group(all P＜0.001);the serum PCT level in the observation group was lower than that in the control group[(1.12±0.17)μg/L vs.(2.71±0.23)μg/L],with a statistically significant difference(t=40.472,P＜0.001).There was no statistically significant difference in the total incidence of adverse reactions between the observation group and the control group[9.43％(5/53)vs.7.55％(4/53),x2=0.121,P=0.727].Conclusion There are multiple treatment options for children with bronchial pneumonia,but the choice of aerosol inhalation of budesonide+ipratropium bromide has distinct advantages,which can improve their immune function,promote the repair of lung injury,reduce their inflammatory response,and promote the disappearance of symptoms and signs as soon as possible,with guaranteed safety and high promotion value.关键词
支气管肺炎/临床症状/布地奈德/异丙托溴铵/小儿Key words
Bronchopneumonia/Clinical symptoms/Budesonide/Ipratropium bromide/Children引用本文复制引用
陈利娟,刘晓丹,陈敏,姜小花..布地奈德联合异丙托溴铵雾化治疗小儿支气管肺炎的疗效分析[J].国际医药卫生导报,2023,29(23):3443-3447,5.基金项目
徐州医科大学附属医院发展基金资助项目(XFFM2021039)Project Supported by the Development Fund of Xuzhou Medical University Affiliated Hospital(XFFM2021039) （XFFM2021039）
