摘要
Abstract
Objective To explore the distribution of antibodies and Rh antigens in transfusion patients with positive antibodies screened in our hospital.Methods From October 1,2019 to December 31,2022,there were 34,796 patients undergoing irregular antibody screening in Sun Yat-sen Memorial Hospital of Sun Yat-sen University,antibody identification and Rh blood typing results of positive patients were collected.Meanwhile,the age,sex,pregnancy history,blood transfusion history and other basic data of 34 796 patients were collected,and the positive rate of irregular antibody production and related influencing factors of blood group system were analyzed.Results Among the 34,796 patients,237 patients were screened positive for irregular antibodies,and the antibody screening positivity rate was 0.68%.A total of 260 cases of irregular antibodies were detected,83 cases of MNS system,accounting for 31.93%;70 cases of Rh blood group system,accounting for 26.93%;14 cases of Lewis blood group system,accounting for 5.39%.There were 79 cases of homozygous non-specific antibodies,with a detection rate of 30.38%.The highest percentage of homo-specific antibodies was anti-E,accounting for 20.77%,followed by anti-Mia,accounting for 20.39%.Rh antigen typing was performed in 237 antibody-screening positive patients,and the highest percentage of CCDee antigen phenotype was 52.74%,followed by CcDEe with 29.16%.Antibody screening positive rate was correlated with gender,blood transfusion history and pregnancy history,and the positive rate was higher in female,patients with blood transfusion history and pregnancy history,and the difference was statistically significant(P＞0.05).There were differences in the positive detection rate of antibody-screening in different departments,and the differences were statistically significant(P＞0.05),and the highest positive rates were in Department of Rheumatology and Immunology and Hematology.Conclusions Anti-E,anti-Mia are the main erythrocyte irregular antibodies,and the production of irregular antibodies is related to gender,transfusion history and pregnancy history,and irregular antibody screening,identification and Rh antigen typing before transfusion are beneficial to improve transfusion safety.关键词
不规则抗体筛查/Rh抗原分布/输血安全Key words
irregular antibody screening/Rh antigen distribution/blood transfusion safety
