脂蛋白相关磷脂酶A2在急性冠状动脉综合征中作用的研究进展OACSTPCD
Research progress on the role of lipoprotein-associated phospholipase A2 in acute coronary syndrome
脂蛋白相关磷脂酶A2(Lp-PLA2)是一种由 441 个氨基酸组成的蛋白.Lp-PLA2 能够促进炎细胞向炎性反应部位聚集及炎性因子的释放,促进基质金属蛋白酶的合成,使动脉粥样硬化斑块内泡沫细胞及细胞外基质增多,并且使斑块纤维帽变薄而易于破裂,进而促进急性冠脉综合征(ACS)的发病.因此在急性冠脉综合征患者中测定和调节Lp-PLA2 水平具有重要的临床意义.
Lipoprotein-associated phospholipase A2(Lp-PLA2)is a protein composed of 441 amino acids,which can promote the aggregation of inflammatory cells to the inflammatory response site and the release of inflammatory factors.It can promote the synthesis of matrix metalloproteinases,increase the number of foam cells and extra cel-lular matrix in atherosclerotic plaque,attenuate plaque fiber cap and prone to rupture,thus promote the onset of acute coronary syndrome(ACS).Therefore,the determination and regulation of Lp-PLA2 levels in patients with ACS are clinically significant.
郭健宏;王亚玲;崔文光
河北北方学院附属第一医院 心血管内科, 河北 张家口 075000
临床医学
脂蛋白相关磷脂酶A2急性冠脉综合征动脉粥样硬化
lipoprotein-associated phospholipase A2acute coronary syndromeatherosclerosis
《基础医学与临床》 2024 (001)
103-107 / 5
张家口市科学技术研究与发展计划(1911021D-1)
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