基础医学与临床2024，Vol.44Issue(1)：108-113,6.DOI:10.16352/j.issn.1001-6325.2024.01.0108
诱导肝星状细胞铁死亡治疗肝纤维化的研究进展
Progress of researches on inducing hepatic stellate cell ferroptosis for treatment of liver fibrosis
摘要
Abstract
Emerging evidence suggests that ferroptosis,an iron-dependent form of regulated cell death,plays a criti-cal role in the genesis of liver fibrosis through inducing hepatic stellate cell(HSC)ferroptosis to inhibit liver fibrosis or inducing hepatic ferroptosis to potentiates liver fibrosis.Pharmacologically targeting at ferroptosis with its inducers can slow down the progression of liver fibrosis in vitro and in vivo model.This review suggests that pharmacological in-duction of HSC ferroptosis might be used as a potential novel targeted therapy for the treatment of liver fibrosis.关键词
肝纤维化/肝星状细胞/铁死亡Key words
liver fibrosis/hepatic stellate cell/ferroptosis分类
医药卫生引用本文复制引用
孙立杰,郝丹丹..诱导肝星状细胞铁死亡治疗肝纤维化的研究进展[J].基础医学与临床,2024,44(1):108-113,6.基金项目
内蒙古自然科学基金(2022MS08032) （2022MS08032）
