基础医学与临床2024，Vol.44Issue(1)：114-118,5.DOI:10.16352/j.issn.1001-6325.2024.01.0114
低氧诱导因子-1α在糖尿病肾病中作用机制的研究进展
Research progress of hypoxia inducible factor 1α in the mechanism of diabetic kidney disease
摘要
Abstract
Hypoxia-inducible factor-1α(HIF-1α)is a nuclear transcription factor.Under high glucose and hypoxia conditions,the expression of HIF-1α is elevated,result in the increased expression of its downstream target genes VEGF,HO-1 and BNIP3,which affect angiogenesis,extra cellular matrix deposition,iron metabolism,and mito-phagy,participating in the occurrence and development of diabetic kidney disease(DKD).In addition,HIF-1α promotes inflammation and renal fibrosis by affecting the production of cytokines in DKD.关键词
低氧诱导因子-1α/糖尿病肾病/发病机制Key words
hypoxia inducible factor 1α/diabetic kidney disease/pathogenesis分类
医药卫生引用本文复制引用
张雅慧,白琼..低氧诱导因子-1α在糖尿病肾病中作用机制的研究进展[J].基础医学与临床,2024,44(1):114-118,5.基金项目
北京大学第三医院临床重点项目(BYSYZD2021036) （BYSYZD2021036）
北京大学第三医院人才孵育基金(BYSYFY2021025) （BYSYFY2021025）
