基础医学与临床2024，Vol.44Issue(1)：119-123,5.DOI:10.16352/j.issn.1001-6325.2024.01.0119
羟酰辅酶A脱氢酶在癌中作用机制的研究进展
Progress of the effect of hydroxyacyl-coenzyme A dehydrogenase in cancer development and its mechanism
摘要
Abstract
A close relationship between fatty acid metabolism and cancer development is well-established.The hydroxyacyl-coenzyme a dehydrogenase(HADH),a key enzyme in fatty acid beta-oxidation,has recently been identified as an anti-oncogenic factor in various cancers and an oncogenic factor in conditions like acute myeloid leukemia.In cancer cells,HADH not only directly catalyzes fatty acid beta-oxidation but also indirectly influences multiple signaling pathways such as PPAR,TNF-α,JAK-STAT3,PI3K/Akt,IFN-γ,MAPK,and non-canonical Wnt signaling pathways,affecting cancer cell proliferation and migration.HADH shows promise as a potential tumor biomarker for diagnosis,treatment,and prognosis in different cancer types,holding significant clinical value.关键词
羟酰辅酶A脱氢酶/脂代谢/脂肪酸β-氧化/抑癌基因/肿瘤标志物Key words
hydroxyacyl-coenzyme A dehydrogenase/lipid metabolism/fatty acid β-oxidation/tumor suppressor gene/tumor marker分类
医药卫生引用本文复制引用
吴国嘏,翟书杰,孙笑,黄怡然,李咏梅,孙丽..羟酰辅酶A脱氢酶在癌中作用机制的研究进展[J].基础医学与临床,2024,44(1):119-123,5.基金项目
天津市教委课题重点项目(2022ZD055) （2022ZD055）
天津医科大学第二医院青年孵育基金(2020ydey13) （2020ydey13）
