中国当代医药2023，Vol.30Issue(34)：41-45,5.
四联疗法联合盐酸小檗碱治疗幽门螺杆菌感染的临床效果
Clinical efficacy of quadruple therapy combined with Berberine Hy-drochloride in the treatment of Helicobacter pylori infection
摘要
Abstract
Objective To investigate the clinical efficacy of quadruple therapy combined with berberine hydrochloride in the treatment of helicobacter pylori(Hp)infection.Methods A total of 68 patients with Hp infection admitted to Xingguo Hospital Affiliated to Gannan Medical University from August 2021 to August 2022 were selected as the study objects.They were divided into control group and observation group by random number table method,with 34 patients in each group.Patients in control group were treated with quadruple therapy(Rabeprazole+Amoxicillin+Metronidazole+Bismuth Citrate Capsules),observation group were treated with quadruple therapy combined with berberine hydrochloride.The improvement time of clinical symptoms,intestinal flora(enterobacter,lactobacillus,enterococcus,bifidobacterium),inflammatory factors[tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6)],occurrence of ad-verse reactions,Hp eradication rate and 3-month recurrence rate of the two groups were compared.Results The disappear-ance time of abdominal distension,abdominal pain,heating and acid reflux in the observation group were shorter than that in the control group,the difference was statistically significant(P＜0.05).After treatment,the levels of enterobacter,lacto-bacillus and bifidobacterium in two groups were higher than those before treatment,while the levels of enterococcus,enter-obacter and serum TNF-α,hs-CRP and IL-6 were lower than those before treatment,the differences were statistical significant(P＜0.05).The levels of lactobacillus and bifi-dobacterium in observation group were higher than those in control group,and the levels of enterobacter,and serum TNF-α,hs-CRP and IL-6 were lower than those of control group,and the differences were statistically significant(P＜0.05).The total incidence of adverse reactions in observation group was lower than that of control group(5.88％vs.23.53％),and the difference was statistically significant(P＜0.05).Af-ter treatment,the eradication rate of Hp in observation group was higher than that in control group(94.12％vs.76.47％),and the difference was statistically significant(P＜0.05).The patients were followed up for 3 months,and no patients were lost to follow-up during the follow-up period,and no patients in the observation group had relapse.There were 4 cases of recurrence in the control group,and the recurrence rate was 11.76％.The recurrence rate at 3 months in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).Conclusion Quadruple therapy combined with Berberine Hydrochloride is effective in the treatment of Hp infection,which can reduce clinical symptoms,regulate intestinal flora,reduce inflammatory factors,improve the eradication rate of Hp,and reduce the rate of adverse reactions and recurrence.关键词
幽门螺杆菌/四联疗法/盐酸小檗碱/疗效Key words
Helicobacter pylori/Quadruple therapy/Berberine Hydrochloride/Curative effect分类
医药卫生引用本文复制引用
朱圣伟,钟琴,陈义华..四联疗法联合盐酸小檗碱治疗幽门螺杆菌感染的临床效果[J].中国当代医药,2023,30(34):41-45,5.基金项目
江西省赣州市指导性科技计划项目(GZ2021ZSF654). （GZ2021ZSF654）
