国际口腔医学杂志2024，Vol.51Issue(1)：10-20,11.DOI:10.7518/gjkq.2024019
基于胱氨酸-谷氨酸反向转运体的抗肿瘤代谢治疗新策略
The new strategies of antimetabolic therapy of cancers based on antiporter of cystine and glutamate
摘要
Abstract
Metabolism reprogram is one of the major characteristics of malignant cancer.It promotes survival of tumor cells and launches the malignant progression of cancers under the nutrition-deficient tumor milieu.Several recent studies have revealed that the antiporter of cystine and glutamine,system Xc-,is a key target of ferroptosis and also impairs flexi-bility of tumor metabolism remolding and promotes dependency on glucose.This finding indicates that interfering glu-cose uptake and glucose metabolism are potential methods of treating system Xc-overexpression cancers.This review summarizes the expressional regulation and metabolic functions of system Xc-,thereby paving a new avenue for the anti-metabolic therapy of cancers.关键词
代谢重编程/胱氨酸-谷氨酸反向转运体/谷氨酰胺/还原型烟酰胺腺嘌呤二核苷酸磷酸Key words
metabolism reprogram/antiporter of cystine and glutamate/glutamine/reduced nicotinamide adenine dinucleotide phosphate分类
医药卫生引用本文复制引用
王苗,孟婉蓉,李龙江..基于胱氨酸-谷氨酸反向转运体的抗肿瘤代谢治疗新策略[J].国际口腔医学杂志,2024,51(1):10-20,11.基金项目
National Natural Science Foundation of China(81972538,82141130) 国家自然科学基金(81972538,82141130) （81972538,82141130）
