基于胱氨酸-谷氨酸反向转运体的抗肿瘤代谢治疗新策略OA
The new strategies of antimetabolic therapy of cancers based on antiporter of cystine and glutamate
代谢重编程是恶性肿瘤的重要特征之一,是促使肿瘤细胞在营养匮乏的情况下存活并促进其恶性进展的重要原因.近些年研究发现,胱氨酸-谷氨酸反向转运体(system Xc-)不仅是诱导铁死亡的关键靶点,同时对肿瘤代谢起重要调控作用,该转运体是导致肿瘤细胞对葡萄糖高度依赖的原因之一,这提示对于高表达system Xc-的肿瘤,抑制葡萄糖摄取及糖代谢是一种有效的治疗策略.本文从system Xc-的表达调控、功能及其对肿瘤代谢的影响等方面进行综述,以期为抗肿瘤代谢治疗提供新思路.
Metabolism reprogram is one of the major characteristics of malignant cancer.It promotes survival of tumor cells and launches the malignant progression of cancers under the nutrition-deficient tumor milieu.Several recent studies have revealed that the antiporter of cystine and glutamine,system Xc-,is a key target of ferroptosis and also impairs flexi-bility of tumor metabolism remolding and promotes dependency on glucose.This finding indicates that interfering glu-cose uptake and glucose metabolism are potential methods of treating system Xc-overexpression cancers.This review summarizes the expressional regulation and metabolic functions of system Xc-,thereby paving a new avenue for the anti-metabolic therapy of cancers.
王苗;孟婉蓉;李龙江
口腔疾病防治全国重点实验室 国家口腔医学中心 国家口腔疾病临床医学研究中心四川大学华西口腔医院头颈肿瘤外科 成都 610041
口腔医学
代谢重编程胱氨酸-谷氨酸反向转运体谷氨酰胺还原型烟酰胺腺嘌呤二核苷酸磷酸
metabolism reprogramantiporter of cystine and glutamateglutaminereduced nicotinamide adenine dinucleotide phosphate
《国际口腔医学杂志》 2024 (001)
长链非编码RNA AC012181.2通过调控细胞内信号网络影响口腔癌增殖、凋亡及侵袭转移的机制研究
10-20 / 11
National Natural Science Foundation of China(81972538,82141130) 国家自然科学基金(81972538,82141130)
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