中国当代医药2023，Vol.30Issue(34)：50-54,5.
左西孟旦联合阿托伐他汀治疗急性心肌梗死合并心力衰竭的临床效果
Clinical effect of Levonimendan combined with Atorvastatin in the treat-ment of acute myocardial infarction complicated with heart failure
摘要
Abstract
Objective To investigate the clinical effect of Levonimendan combined with Atorvastatin in the treatment of a-cute myocardial infarction(AMI)complicated with heart failure.Methods A total of 65 patients with AMI complicated with heart failure admitted to the First People's Hospital of Fuzhou from February 2021 to February 2023 were selected as the re-search objects,and they were divided into control group(32 cases)and combined group(33 cases)according to the random number table method.The control group was treated with Levosimendan,and the combined group was treated with Levosi-mendan+Atorvastatin.The clinical efficacy,hemodynamic indexes,lipid metabolism indexes,cardiac function indexes and adverse reactions were compared between the two groups.Results The total effective rate of the combined group was 93.94％(31/34),which was higher than 71.88％(23/32)of the control group,and the difference was statistically significant(P＜0.05).After treatment,the left ventricular ejection fraction(LVEF),human cardiac index(CI)and stroke volume(SV)of the two groups were higher than those before treatment,and the LVEF,CI and SV of the combined group were higher than those of the control group,and the differences were statistically significant(P＜0.05).After treatment,the total cholesterol(TC)and triglyceride(TG)levels of the combined group were lower than those of the control group,and the high-density lipopro-tein cholesterol(HDL-C)was higher than that of the control group,and the differences were statistically significant(P＜0.05).After treatment,the levels of brain natriuretic peptide(BNP),high-sensitivity C-reactive protein(hs-CRP),creatine kinase-MB(CK-MB)and cardiac troponin Ⅰ(cTnⅠ)in the two groups were lower than those before treatment,and the levels of BNP,hs-CRP,CK-MB and cTnⅠ in the combined group were lower than those in the control group,with statistically significant differences(P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Compared with Levosimendan alone,combined with Atorvastatin in the treatment of AMI complicated with heart failure can effectively improve the clinical effect,improve the cardiac function,hemodynamics and lipid metabolism of patients,reduce the levels of serum hs-CRP,BNP,CK-MB and cTnⅠ,and has good safety.关键词
急性心肌梗死/心力衰竭/脂代谢/心功能/阿托伐他汀/左西孟旦Key words
Acute myocardial infarction/Heart failure/Lipid metabolism/Cardiac function/Atorvastatin/Levosimendan分类
医药卫生引用本文复制引用
雷平平,江玉辉..左西孟旦联合阿托伐他汀治疗急性心肌梗死合并心力衰竭的临床效果[J].中国当代医药,2023,30(34):50-54,5.基金项目
江西省卫生健康委科技计划项目(20202115). （20202115）
