中国当代医药2023，Vol.30Issue(35)：106-110,封4,6.
系统免疫炎症指数在输尿管尿路上皮癌中的预后价值
Prognostic value of systemic immune-inflammatory index in ureteral urothelial carcinoma
摘要
Abstract
Objective To investigate the value of preoperative systemic immune-inflammation index(SII)in prognostic risk stratification evaluation of patients with ureteral urothelial carcinoma.Methods The clinical data of 202 patients with ureteral urothelial carcinoma admitted to the Department of Urology,the First Affiliated Hospital of Hebei North University from January 2005 to December 2019 were retrospectively analyzed.The preoperative blood SII of patients was sorted out and analyzed,and the best cut value of SII was determined as 580 by using the highest Youden index value.Cox regression analysis was then performed.Concordance indices and decision curve analysis were used to assess the discrimination of the predictive models.Results A total of 55 patients(27％)had high levels of SII(SII＞580).In multivariate analysis,high SII was associated with progression to PFS(hazard ratio=1.75,95％CI=1.21-2.65,P=0.002)and CSS(hazard ratio=2.23,95％CI=1.38-4.25,P=0.002).Conclusion Preoperative SII can identify patients with poor disease and prognosis of ureteral urothelial carcinoma.This more readily available biomarker may aid decision making regarding adjuvant therapy for patients with ureteral urothelial carcinoma.关键词
系统免疫炎症指数/输尿管尿路上皮癌/生存/生物标志物/预后Key words
Systemic immune-inflammatory index/Ureteral urothelial carcinoma/Survive/Biomarker/Prognosis分类
医药卫生引用本文复制引用
陈怀安,刘硕,张潮,王哲,苗文隆..系统免疫炎症指数在输尿管尿路上皮癌中的预后价值[J].中国当代医药,2023,30(35):106-110,封4,6.基金项目
河北省医学科学研究课题计划项目(20211529). （20211529）
