中国当代医药2023，Vol.30Issue(34)：64-66,71,4.
胎儿颈项透明层增厚与染色体异常、妊娠结局的关系
Relationship between the thickening of the fetal nuchal translucency and chromosome abnormality,pregnancy outcome
摘要
Abstract
Objective To investigate the relationship between fetal nuchal translucency(NT)thickening and chromosome abnormality,pregnancy outcome.Methods A total of 120 patients with fetal NT thickening at 11-13+6 weeks of gestation were retrospectively analyzed in Ganzhou Maternal and Child Health Hospital from January 2019 to December 2020.The results of fetal chromosome examination and abnormal ultrasonic structure were analyzed,and the pregnancy outcome and postnatal condition were followed up.Results Among the 120 cases of NT thickening,100 cases(83.33％)had normal preg-nancy,and 20 cases(16.67％)were diagnosed as chromosomal diseases and induced labor.Among them,7 fetuses were de-tected as chromosomal karyotype abnormalities and 13 fetuses were detected as copy number variations by chromosome mi-croarray analysis test.In 100 normal pregnancies,the incidence of chromosome abnormality was 20.00％(20/100),which was higher than that of normal population,and the difference was statistically significant(P＜0.05).Among normal pregnan-cies,the incidence of chromosomal abnormalities in pregnant women＜35 years old is lower than that in pregnant women≥ 35 years old,the difference was statistically significant(P＜0.05).The rate of chromosomal abnormality in patients with abnormal ultrasound structure was higher than that in patients with normal ultrasound structure,the difference was statisti-cally significant(P＜0.05).Conclusion It can be seen from the above results that the incidence of chromosome abnormality of fetus with NT thickening increases when the pregnant woman is older than 35 years and the ultrasound structure is abnor-mal.Chromosome karyotype examination with NT thickening showed that the pregnancy outcome and fetal postnatal condi-tion of the abnormal chromosome were poor.关键词
颈项透明层/胎儿/染色体异常/妊娠结局/相关性Key words
Nuchal translucency/Fetus/Chromosome abnormalities/Pregnancy outcome/Relevance分类
医药卫生引用本文复制引用
黄素珍,崔园英,刘萍,胡莉琴..胎儿颈项透明层增厚与染色体异常、妊娠结局的关系[J].中国当代医药,2023,30(34):64-66,71,4.基金项目
江西省赣州市指导性科技计划项目(GZ2021ZSF276). （GZ2021ZSF276）
