健康研究2023，Vol.43Issue(6)：700-704,5.DOI:10.19890/j.cnki.issn1674-6449.2023.06.020
膳食炎症指数评分改变与类风湿关节炎疾病活动度的关系
Relationship between change in dietary inflammatory index and rheumatoid arthritis disease activity
摘要
Abstract
Objective To analyze the association between change in dietary inflammation index(DII)and rheumatoid arthritis(RA)disease activity.Methods The dietary intake of patients with RA(129 in total)and healthy controls(131 in total)over a period of three months was examined with the use of the food frequency questionnaire(FFQ)to calculate the DII.Additionally,the disease activity of patients with RA was assessed through the disease activity assessment at 28 joints-erythrocyte sedimentation rate(DAS28-ESR).One hundred and eighteen patients diagnosed with rheumatoid arthritis and exhibiting stable disease were randomly allocated into two groups,one receiving a Mediterranean dietary intervention for a duration of 4 months and the other following a conventional diet.DAS28-ESR and DII were determined.Results DII scores were significantly higher in patients with RA than in healthy controls(P=0.011).However,no significant correlation was observed between DII scores and disease activity in RA patients(P＞0.05).Notably,anti-inflammatory changes in DII scores were associated with maintaining low disease activity over a period of two years(OR=7.17,95%CI 2.53-20.28,P＜0.001).Following a four-month intervention,it was observed that the DII scores and DAS28-ESR scores of the Mediterranean diet group were lower than their initial values.The conventional diet group also experienced lower DAS28-ESR scores.Both differences were deemed to be statistically significant(P＜0.05).Conclusions The inflammatory impact of diet was higher in RA patients compared to healthy individuals,and variations in DII scores indicative of anti-inflammatory changes were linked with sustained low disease activity in RA patients.The Mediterranean diet exhibits the potential to ameliorate disease activity in patients suffering from RA.关键词
膳食炎症指数/类风湿关节炎/疾病活动度Key words
dietary inflammatory index/rheumatoid arthritis/disease activity分类
医药卫生引用本文复制引用
许瑜佳,王友庆,陈士芳..膳食炎症指数评分改变与类风湿关节炎疾病活动度的关系[J].健康研究,2023,43(6):700-704,5.基金项目
浙江省医药卫生科技计划项目(2022RC073) （2022RC073）
