中国当代医药2023，Vol.30Issue(35)：123-126,131,5.
耳声发射和听觉脑干反应在巨细胞病毒相关听力损伤小儿筛查中的重要性及防治策略
Importance of otoacoustic emission and auditory brainstem response in the screening of children with cytomegalovirus associated hearing loss and the prevention and treatment strategies
摘要
Abstract
Objective To investigate the importance of otoacoustic emission(OAE)and auditory brainstem response(ABR)in the screening of children with cytomegalovirus(CMV)associated hearing loss and the prevention and treatment strategies.Methods The clinical data of 160 newborns born in Ganzhou Women and Children's Health Care Hospital from January to December 2022 were retrospectively analyzed.According to the presence or absence of CMV infection,they were divided into the observation group(CMV infection,n=80)and the control group(no CMV infection,n=80).OAE and ABR examina-tions were performed,and the risk factors affecting children with different degrees of hearing loss were analyzed.Results The passing rates of initial screening transiently evoked otoacoustic emission(TEOAE),secondary screening TEOAE,sec-ondary screening distortion product otoacoustic emission(DPOAE),and secondary screening ABR in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).Among the 160 ears screened in the observation group,145 ears were re-screened by ABR,and 15 ears were confirmed to have hearing loss.The rate of mild hearing loss was 46.67％,the rate of moderate hearing loss was 33.33％,and the rate of severe hearing loss was 20.00％.Univariate analysis showed that there were significant differences in different platelet counts,urine CMV-DNA vi-ral load,and blood CMV-DNA viral load between children with hearing impairment and those with normal hearing(P＜0.05).Multivariate logistic regression analysis showed that platelet count(β=1.265,OR=3.254,95％CI=1.245-8.461),CMV-DNA viral load(β=0.982,OR=2.584,95％C/=1.105-8.265)and urine CMV-DNA load(β=1.156,OR=3.984,95％CI=1.102-8.365)were the influencing factors of severe hearing loss related to CMV infection(P＜0.05).Conclusion OAE and ABR can ef-fectively screen for hearing loss in children caused by CMV infec tion,and ABR test can also determine the severity of the disease.Changes in platelet count and CMV-DNA viral load may lead to hearing loss in neonates with CMV infection.Only early screening of neonates with CMV infection should be strengthened.Targeted intervention should be carried out accord-ing to its influencing factors to reduce the risk of neonatal hearing loss.关键词
耳声发射/听觉脑干反应/巨细胞病毒相关听力损失小儿/防治策略研究Key words
Otoacoustic emission/Auditory brainstem response/Children with cytomegalovirus associated hearing loss/Research on prevention and control strategies分类
医药卫生引用本文复制引用
谢婷,刘爱萍,李彩云,朱友莲,黄姝花,邱小兵..耳声发射和听觉脑干反应在巨细胞病毒相关听力损伤小儿筛查中的重要性及防治策略[J].中国当代医药,2023,30(35):123-126,131,5.基金项目
江西省卫生健康委科技计划项目(202312028). （202312028）
