国际口腔医学杂志2024，Vol.51Issue(1)：74-81,8.DOI:10.7518/gjkq.2024009
口腔局部麻醉药抗菌机制的研究进展
Research progress on the antibacterial mechanism of oral local anesthetics
摘要
Abstract
Local anesthetic is a kind of drug commonly used in oral outpatient operations.It has anesthetic and analge-sic effects,and it can alleviate the pain of patients and facilitate treatment.Many studies have shown that local anesthetics have antibacterial effects,and they can effectively inhibit the growth of various bacteria and fungi.In this paper,the anti-bacterial effects of local anesthetics commonly used in dentistry(lidocaine,bupivacaine,ropivacaine,articaine,etc.)were summarized,and their molecular mechanisms were discussed(including changes in cell wall and membrane permeability,direct damage to cell membranes,inhibition of protein and genetic material synthesis,inhibition of cell respiration,etc.).The interaction with other drugs(antibiotics,epinephrine,opioids,etc.)also were studied.This work will be helpful in the selection of local anesthetics in oral clinics and the prevention and control of infection.关键词
局部麻醉药/抗菌性/口腔医学Key words
local anesthetics/antibacterial/dentistry分类
医药卫生引用本文复制引用
谭永臻,梁新华..口腔局部麻醉药抗菌机制的研究进展[J].国际口腔医学杂志,2024,51(1):74-81,8.基金项目
Interdisciplinary Innovation Project of West China Hospital of Stomatology,Sichuan University(RD-03-202004) 四川大学华西口腔医院交叉学科创新项目(RD-03-202004) （RD-03-202004）
