中国当代医药2023，Vol.30Issue(34)：106-109,114,5.
复方苦参注射液治疗后肺癌化疗患者肾毒性的影响因素及血清肌酐预测肾毒性的价值分析
Analysis of influencing factors of nephrotoxicity in patients with lung can-cer chemotherapy after Compound Kushen Injection and value of serum creatinine on predicting nephrotoxicity
摘要
Abstract
Objective To study the influencing factors of nephrotoxicity in patients with lung cancer chemotherapy after Compound Kushen Injection and application value of serum creatinine(SCr)on predicting nephrotoxicity.Methods Retro-spective analysis was performed on the clinical data of 60 patients with lung cancer treated with chemotherapy in Dongxin Fifth Hospital of Shangrao City from May 2020 to May 2022.All patients were treated with Compound Kushen Injection.According to the occurrence of nephrotoxicity,the patients were divided into nephrotoxicity group(n=19)and non-nephro-toxicity group(n=41).Independent risk factors of nephrotoxicity in patients with lung cancer chemotherapy were analyzed by logistic regression analysis,and ROC was drawn to evaluate the application value of SCr monitoring of Compound Kushen Injection on alleviating the nephrotoxicity in patients with lung cancer chemotherapy.Results Univariate analysis showed that the proportions of patients with body mass index(BMI)＜18.5 kg/m2,underlying diseases,cisplatin as the main chemotherapy drug and cisplatin/carboplatin chemotherapy ≥4 cycles in nephrotoxicity group were higher than those in non-nephrotoxicity group,the differences were statistally significant(P＜0.05).The levels of SCr,blood urea nitrogen(BUN)and serum uric acid(SUA)were higher in nephrotoxicity group than those in non-nephrotoxicity group,the differences were statistally significant(P＜0.05).Multivariate logistic regression analysis showed that the presence of underlying diseases(β=1.247,OR=3.480,95％CI=1.601-7.562),cisplatin chemotherapy(β=1.522,OR=4.581,95％CI=1.330-15.780)and SCr(β=1.198,OR=3.313,95％C/=1.801-6.096)were independent risk factors for nephrotoxicity in patients with lung cancer chemotherapy(P＜0.05).The AUC,95％CI,sensitivity,specificity and optimal cut-off value of SCr variation rate on predicting nephrotoxicity alleviated by compound Kushen injection in patients with lung cancer chemotherapy were 0.865,0.752-0.940,84.21％,85.37％and 1.2 respectively.Conclusion Presence of underlying disease,cisplatin chemotherapy and high basic SCr level before chemotherapy are independent risk factors of nephrotoxicity in patients with lung cancer chemotherapy after compound Kushen injection.The variation rate of SCr has important value on evaluating the clinical ef-fects of Compound Kushen Injection on alleviating nephrotoxicity in patients with lung cancer chemotherapy.It is necessary to conduct SCr monitoring during chemotherapy to ensure drug safety.关键词
血清肌酐监测/复方苦参注射液/肺癌化疗/肾毒性Key words
Serum creatinine monitoring/Compound Kushen Injection/Lung cancer chemotherapy/Nephrotoxicity分类
医药卫生引用本文复制引用
洪星,李康..复方苦参注射液治疗后肺癌化疗患者肾毒性的影响因素及血清肌酐预测肾毒性的价值分析[J].中国当代医药,2023,30(34):106-109,114,5.基金项目
江西省中医药管理局科技计划课题(2022B520). （2022B520）
