中国当代医药2023，Vol.30Issue(35)：21-24,4.
亚精胺的抗衰机制及在人体皮肤中的应用前景
Anti-aging mechanisms of spermidine and its application prospects in hu-man skin
摘要
Abstract
Spermidine(SPD)is a low-molecular natural polyamine(PA)that has various functions such as anti-aging and life extension.Recently,significant effectiveness of SPD in skin anti-aging and improvement of skin function has been ob-served.Oxidative stress and autophagy are two important mechanisms of skin antiaging.SPD could inhibit the inflammatory response,reduce the generation of reactive oxygen species(ROS)in mice,prevent lipid peroxidation and exhibit obvious an-tioxidant effects.SPD could also regulate mitochondrial function by affecting the autophagy mechanism,and prevent skin aging by preventing mitochondrial oxidative damage and gene mutation.SPD promoted muscle satellite cell proliferation and prevented muscle aging through autophagy.SPD reduced the photoaging effect of ultraviolet rays on the skin,strengthened the structure of human facial skin,formed a lipid barrier and increased the expression of collagen and elastin in human aging skin.On the other hand,SPD had a repair effect on the traumatized skin of mice,could promote the production of skin melanin and stimulate hair growth.This article reviews the research progress of SPD in skin and its irritation and toxicity,and looks forward to the development and application prospect of SPD in human skin.关键词
亚精胺/细胞自噬/抗衰老/皮肤Key words
Spermidine/Cellular autophagy/Anti-aging/Skin分类
医药卫生引用本文复制引用
阮浩澜,许姿敏,陈琪..亚精胺的抗衰机制及在人体皮肤中的应用前景[J].中国当代医药,2023,30(35):21-24,4.基金项目
广东省药品监督管理局科技创新项目(2022TDZ08). （2022TDZ08）
