中国当代医药2023，Vol.30Issue(35)：75-79,5.
CYP2C19*2/*3基因多态性与急性非致残性缺血性卒中复发的相关性分析
Analysis of correlation between CYP2C19*2/*3 gene polymorphisms and recurrence of acute non-disabling ischemic stroke
摘要
Abstract
Objective To analyze the correlation between CYP2C19*2/*3 gene polymorphisms and prognostic recurrence of acute non-disabling ischemic stroke treated with Clopidogrel regularly.Methods A total of 120 cases of acute non-dis-abling ischemic stroke were enrolled in the group,in the Department of Neurology,Jiujiang First People's Hospital from January 2020 to March 2021.And the polymorphism of CYP2C19 gene was detected by the point of care testing of Jingyin drug gene detection system,the recurrence of ischemic stroke was followed up within one year,and the relationship between stroke recurrence and CYP2C19 gene polymorphism in patients taking Clopidogrel regularly was analyzed.Results A total of 120 patients were followed for one year,and 18(15.00％)of them had stroke recurrence.Compared with fast metaboliz-ers,patients with CYP2C19*2/*3 gene defect had a higher risk of recurrence,the difference was statistically significant(x2=4.804,P＜0.05).The proportion of patients with CYP2C19*2/*3 gene defect type,diabetes,intracranial artery steno-sis and body mass index(BMI),low density lipoprotein cholesterol(LDL-C),homocysteine(Hcy)levels in the recurrence group were higher than those in the non-recurrence group,the differences were statistically significant(P＜0.05).The re-sults of multifactorial logistic regression analysis suggested thatCYP2C19*2/*3genedefect type(β=1.912,OR=9.845,95％CI:5.531-15.479),hypertension(β=1.389,OR=4.242,95％CI:1.185-12.919),diabetes mellitus(β=1.742,OR=5.707,95％CI:1.762-18.479),intracranial artery stenosis(β=1.251,OR=2.875,95％CI:1.195-8.459),BMI(β=1.497,OR=4.469,95％CI:1.648-12.121),LDL-C(β=1.840,OR=7.444,95％CI:1.151-14.147),and Hey(β=1.252,OR=2.352,95％CI:1.280-6.383)were independent risk factors for re-currence of patients with acute non-disabling ischemic stroke(P＜0.05).Conclusion In patients with acute non-disabling ischemic stroke who regularly take Clopidogrel,the CYP2C19*2/*3 gene defect type has a higher risk of stroke recurrence than the fast metabolic type,and the gene defect type is an independent risk factor for stroke recurrence in patients with a-cute non-disabling ischemic stroke.关键词
基因多态性/氯吡格雷/非致残性缺血性卒中/复发Key words
Gene polymorphism/Clopidogrel/High-risk non-disabling ischemic stroke/Recurrence分类
医药卫生引用本文复制引用
汪进丁,万姗姗,罗江洪,徐明,姚德斌,万和斌..CYP2C19*2/*3基因多态性与急性非致残性缺血性卒中复发的相关性分析[J].中国当代医药,2023,30(35):75-79,5.基金项目
江西省卫生健康委员会科技计划项目(202140284). （202140284）
