昆明医科大学学报2023，Vol.44Issue(12)：184-190,7.DOI:10.12259/j.issn.2095-610X.S20231229
吲哚在生物材料表面大肠杆菌生物膜中的研究进展
Research Progress of Indole in E.coli Biofilms on the Surface of Biomaterials
摘要
Abstract
Escherichia coli is a highly adaptable opportunistic pathogen bacterium that can form biofilms on the surface of implants and generates persistent cells,leading to life-threatening infections that are difficult to treat with antibiotics alone.Therefore,there is a need for an effective E.coli biofilm inhibitor to combat this public health threat.Indole is a novel quorum-sensing signaling molecule of E.coli discovered in recent years,which is of great significance in regulating bacterial growth and biofilm formation,and is a potential target for future research on new anti-biofilm preparations.This article reviews the research progress on the formation of Escherichia coli biofilms,the microbial metabolism of indole and its regulation of Escherichia coli biofilm formation,in order to provide information for clinical treatment and drug development.关键词
大肠杆菌/吲哚/细菌生物膜/生物材料/植入感染Key words
Escherichia coli/Indole/Bacterial biofilm/Biomaterials/Implant infection分类
医药卫生引用本文复制引用
苏丹燕,唐文甜,杨谨旭,刘华,李邦胜,赵应鼎,黄云超..吲哚在生物材料表面大肠杆菌生物膜中的研究进展[J].昆明医科大学学报,2023,44(12):184-190,7.基金项目
国家自然科学基金资助项目(81960335) （81960335）
云南省卫生健康委临床医学中心建设项目(ZX2019-05-01) （ZX2019-05-01）
