老年医学与保健2023，Vol.29Issue(6)：1165-1169,5.
糖化血红蛋白的变异性对老年终末期糖尿病肾脏病腹膜透析患者预后的影响
Effect of glycosylated hemoglobin variability on the prognosis of elderly patients with end-stage diabetes nephropathy undergo-ing peritoneal dialysis
张慧 1张蓓蓓 1杨冬冬1
作者信息
- 1. 南通市海门区中医院肾脏内科,江苏南通 226100
- 折叠
摘要
Abstract
Objective To investigate the effect of glycosylated hemoglobin(HbA1c)variability on the clinical out-comes of elderly patients with end-stage diabetes nephropathy undergoing peritoneal dialysis.Methods A total of 85 elderly patients with end-stage diabetes nephropathy undergoing peritoneal dialysis in Traditional Chinese Medicine Hospital of Haimen District from June 2013 to June 2022 were retrospectively included.They were divided into 4 groups according to HbA1c varia-bility.The HbA1c variability was defined as the coefficient of variation(CV)for each patient,which was the ratio of the standard deviation of HbA1c to the mean of HbA1c.COX regression was used for analysis.Results Out of 85 patients,44 died(55.3%).The results of multivariate analysis showed that HbA1c CV＞2.83 was a significant risk factor affecting patient survival(HR =2.88,95%CI 1.21-5.55,P＜0.001).The Kaplan Meier analysis results showed that the survival rate of pa-tients decreased with the increase of HbA1c CV.Conclusion Elevated HbA1c variability significantly increases the all-cause mortality in elderly patients with diabetes nephropathy undergoing peritoneal dialysis.Reducing HbA1c variability may be a key strategy to improve patient outcomes.关键词
老年/糖尿病/腹膜透析/糖化血红蛋白/血糖变异Key words
elderly/diabetes/peritoneal dialysis/glycosylated hemoglobin/blood glucose variability引用本文复制引用
张慧,张蓓蓓,杨冬冬..糖化血红蛋白的变异性对老年终末期糖尿病肾脏病腹膜透析患者预后的影响[J].老年医学与保健,2023,29(6):1165-1169,5.
