老年医学与保健2023，Vol.29Issue(6)：1170-1174,5.
适合老年2型糖尿病患者的每日2次德谷门冬双胰岛素剂量分配方案探讨
Study on the dosage distribution scheme of IDegAsp twice a day for elderly patients with type 2 diabetes
摘要
Abstract
Objective The application experience of IDegAsp in elderly patients with type 2 diabetes was limited.This study was to explore a twice daily IDegAsp doseage distribution scheme for elderly patients with diabetes.Methods 278 elder-ly patients with type 2 diabetes were selected from Department of Endocrinology of Huadong Hospital from March 2020 to June 2023.All of them received a stable dose of IDegAsp or premixed insulin twice a day,and with HbA1c＜7%.Continuous blood glucose monitoring confirmed that the time within the target range(TIR)of glucose was＞70%,and the time below the target range(TBR)of glucose was＜1%.The daily total insulin dosage,pre-breakfast insulin dosage,pre-dinner insulin dos-age,and ratio of pre-breakfast/pre-dinner insulin dosage were compared among the groups.Results The average dosage of the total insulin,pre-breakfast insulin and pre-dinner insulin of the IDegAsp group were(27.8±8.0)U/d,(17.0±4.8)U/d,and(10.8±4.1)U/d,respectively.Its median ratio of pre-breakfast/pre-dinner insulin dosage was 1.6,which was higher than that of the other premixed insulin groups(1.4)(P =0.022).The level of fasting C-peptide was negatively corre-lated with the ratio of pre-breakfast/pre-dinner insulin dosage(r =-0.301,P =0.016),and positively correlated with pre-din-ner insulin dosage(r =0.247,P =0.049).Conclusion The initial dose of IDegAsp for elderly patients with diabetes can be distributed at a ratio of 1.6∶1 before breakfast and dinner,rather than the generally recommended 1∶1.If it is converted from other types of premixed insulin,it is recommended to appropriately reduce the pre-dinner dosage,and the poorer the pancreatic function,the smaller pre-dinner dosage.关键词
老年/2型糖尿病/德谷门冬双胰岛素,预混胰岛素/连续血糖监测Key words
elderly/type 2 diabetes/IDegAsp,premixed insulin/continuous blood glucose monitoring引用本文复制引用
邱婕萸真,蒋翠萍,李圆,黄宇新,陶晓明,孙皎..适合老年2型糖尿病患者的每日2次德谷门冬双胰岛素剂量分配方案探讨[J].老年医学与保健,2023,29(6):1170-1174,5.基金项目
国家自然科学基金青年项目(82000778) （82000778）
