临床误诊误治2023，Vol.36Issue(8)：89-93,5.DOI:10.3969/j.issn.1002-3429.2023.08.019
支气管哮喘急性发作期患儿血清ICAM-1、IL-17与IL-8变化及临床意义
Changes and Clinical Significance of Serum ICAM-1,IL-17,and IL-8 in Children with Acute Exacerbation of Bronchial Asthma
摘要
Abstract
Objective To analyze the changes and clinical significance of serum cell adhesion molecule-1(ICAM-1),interleukin-17(IL-17)and interleukin-8(IL-8)in children with acute exacerbation of bronchial asthma.Meth-ods In total,95 children with acute exacerbation of bronchial asthma treated from February 2019 to February 2022 were se-lected as the observation group,and 99 healthy children undergoing physical examination during the same period were selected as the control group.Serum levels of ICAM-1,IL-17 and IL-8 were compared between the two groups,and were recorded in children with different disease conditions.Multivariate Logistic regression analysis was used to investigate the risk factors af-fecting asthma control in children.Results The levels of ICAM-1,IL-17 and IL-8 in the observation group were higher than those in the control group(P＜0.01).The levels of serum ICAM-1,IL-17 and IL-8 in children with more severe disease were also gradually increased(P＜0.05).Multivariate Logistic regression analysis showed that serum ICAM-1,IL-17 and IL-8 levels were independent risk factors affecting the control level of bronchial asthma in children(P＜0.05,P＜0.01).Conclu-sion The levels of serum ICAM-1,IL-17 and IL-8 in children with acute exacerbation of bronchial asthma are significantly increased,which has an important relationship with the occurrence and development of the disease.关键词
哮喘/儿童/细胞黏附分子-1/白细胞介素-17/白细胞介素-8/哮喘控制/危险因素/病情程度Key words
Asthma/Child/Cell adhesion molecules-1/Interleukin-17/Interleukin-8/Asthma control/Risk fac-tors/Severity of disease分类
医药卫生引用本文复制引用
彭定玉,赖春连,韦家美,刘倩华,班健,裴河欢..支气管哮喘急性发作期患儿血清ICAM-1、IL-17与IL-8变化及临床意义[J].临床误诊误治,2023,36(8):89-93,5.基金项目
广西自然科学基金项目(2016GXNSFBA380203) （2016GXNSFBA380203）
