中国当代医药2023，Vol.30Issue(34)：4-7,13,封3-封4,7.
基于网络药理学及分子对接分析二陈汤抗肺癌的作用机制
Analysis of mechanism of Erchen Decoction against lung cancer based on network pharmacology and molecular docking
摘要
Abstract
Objective To analyze the mechanism of Erchen Decoction in the treatment of lung cancer by network pharma-cology and molecular docking technology.Methods The components and related targets of Erchen Decoction were obtained through the traditional Chinese medicine system pharmacology database and analysis platform(TCMSP),and the literature search period was from November 24,2022 to March 31,2023.The relevant targets of lung cancer were obtained from GeneCards,OMIM,PharmGKB and other databases,and the intersection genes with the target genes of Erchen Decoction were screened.The PPI network of protein interaction was constructed,and the biological functions and pathways of key proteins were enriched by R language visualization.Molecular docking verified the binding ability of the main active ingre-dients in Erchen Decoction to target proteins.Results There were 142 kinds of active components,229 active component targets and 227 common targets with lung cancer in Erchen Decoction.Biological functions involve foreign biological stimuli,response to lipopolysaccharides and cell response to chemical stress.Pathway enrichment analysis mainly involved advanced glycatien endproducts-receptor for advanced glycation end products signaling pathway,lipid and atherosclerosis pathway,human cytomegalovirus infection pathway,chemical carcinogenic-receptor activation,interleukin-17 signaling pathway,etc.Molecular docking showed that the core target could be stably docked with the active ingredient of the drug.Conclusion Erchen Decoction may play a role in the prevention and treatment of Lung Cancer through a variety of chemically active components such as quercetin,coniferin,and naringenin,with multiple targets and multiple pathways.关键词
二陈汤/肺癌/网络药理学/分子对接Key words
Erchen Decoction/Lung cancer/Network pharmacology/Molecular docking分类
临床医学引用本文复制引用
刘照艳,张亮,孟令占..基于网络药理学及分子对接分析二陈汤抗肺癌的作用机制[J].中国当代医药,2023,30(34):4-7,13,封3-封4,7.基金项目
国家自然科学基金委员会资助项目(81904039) （81904039）
中国博士后科学基金面上资助项目(2022M710551). （2022M710551）
