皮肤性病诊疗学杂志2023，Vol.30Issue(6)：502-508,7.DOI:10.3969/j.issn.1674-8468.2023.06.004
复合中层酸联合30％超分子水杨酸治疗黄褐斑的临床效果
Efficacy of compound middle-layer acid combined with 30％supramolecular salicylic acid for melasma
摘要
Abstract
Objective To evaluate the therapeutic efficacy of a combination of compound mid-dle-layer acid and 30％supramolecular salicylic acid for melasma.Methods Five female pa-tients with melasma who were admitted to our hospital from May 2022 to December 2022 were en-rolled in this study.A self-parallel controlled study was carried out.The patients'treated side was treated with compound middle-layer acid while the control side was treated with 30％supramolecu-lar salicylic acid at weeks 0 and 4.On week 8,the treated side and control side were treated with 30％supramolecular salicylic acid and compound middle-layer acid,respectively.We compared the area score of facial lesions,skin color,sebum,water content and the severity of melasma-re-lated psychological stress between the two sides.Results The combination therapy significantly decreased the area scores on the forehead,cheek and chin(P＜0.05).In contrast,only the area scores on the forehead were decreased on the control side.Although the color scores were de-creased on the forehead,cheek and chin of both sides,significant decrease was observed on the treated side(P＜0.05 vs.the control side).Similarly,both treatments increased sebum con-tent,with a prominent increase on the treated side(P＜0.05 vs.the control side).The changes in water content did not differ significantly between these two treatments(P＞0.10).Moreover,the combination therapy decreased both SAS(from 21.62±5.99 to 20.86±6.44,P＜0.05)and SDS scores(from 25.05±4.21 to 23.33±5.12,P＜0.05).Conclusions The combina-tion therapy of compound middle-layer acid and 30％supramolecular salicylic acid can significant-ly improve the facial skin lesions and psychological state of patients with melasma.Better results can be achieved by using compound middle-layer acid first,followed by 30％supramolecular sali-cylic acid.关键词
黄褐斑/中层复合酸/水杨酸Key words
melasma/compound middle-layer acid/salicylic acid引用本文复制引用
孙钰,叶聪秀,付佼佼,陈欣玲,周峰,蒋雨含,赖维,郑跃..复合中层酸联合30％超分子水杨酸治疗黄褐斑的临床效果[J].皮肤性病诊疗学杂志,2023,30(6):502-508,7.基金项目
国家自然科学基金(81673085 （）
81201241) （）
