摘要
Abstract
Objective To investigate the effect of late night snack on energy metabolism and prognosis in elderly hospi-talized patients with acute-on-chronic liver failure(ACLF),and provide a basis for patient's clinical diagnosis,treatment,and prognosis judgment.Methods A total of 79 elderly ACLF patients admitted to Second Affiliated Hospital of Air Force Medical University from January to December 2020 were selected as the study subjects.They were divided into control group(n =40)and observation group(n =39)according to random number table method.The patient's total daily calories were calculated by a professional nutritionist.The patients in the control group were fed 3 meals regularly.The patients in the observation group had three meals a day during the day,but each meal reduced67 kcal of food(equivalent to 16.7 g of carbohydrates),and a late night snack was added 1 hour before bedtime.The duration of intervention was 2 weeks.The body mass index(BMI),glucose metabolism indexes,nutritional status,biochemical indexes,quality of life and 28-day mortality were compared be-tween the two groups.Results After intervention,the fasting blood glucose level of the observation group was significantly higher than that of the control group,while the incidence of hypoglycemia and insulin resistance index were significantly lower than those of the control group(all P＜0.05).Comparedwiththe control group,the proportionof patientswith NRS2002≥3 in the observation group decreased significantly after intervention,and the 28-day mortality rate decreased significantly(all P＜0.05).Compared with the control group,the levels of albumin,prealbumin and prothrombin activity in the observation group significantly increased after intervention(all P＜0.05).After intervention,the total score and physiological scores of the observation group were significantly higher than those of the control group,indicating that the quality of life of patients in these dimensions was significantly improved.Conclusion In elderly ACLF patients,the late night snack can reduce the incidence of hypoglycemia,improve the nutritional status and quality of life of patients,and reduce the 28-day mortality,which has certain clinical value.关键词
老年/慢加急性肝衰竭/睡前加餐/能量代谢/预后Key words
elderly/acute-on-chronic liver failure/late night snack/energy metabolism/prognosis
