皮肤性病诊疗学杂志2023，Vol.30Issue(6)：509-517,9.DOI:10.3969/j.issn.1674-8468.2023.06.005
线粒体功能障碍导致白癜风的机制:基于生物信息学方法
Bioinformatics-based study on the pathogenic mechanism of vitiligo caused by mitochondri-al dysfunction
摘要
Abstract
Objective To investigate the mechanisms of mitochondrial dysfunction-induced vitiligo based on bioinformatics.Methods The vitiligo target genes were obtained from CTD/Gene Cards/OMIM/NCBI Gene databases,while mitochondrial dysfunction target genes were download-ed from the MITOMAP database,followed by intersection analysis to identify the common genes.The latter were subjected to GO and KEGG enrichment analysis.The core genes were screened by analysis of protein-protein interaction.The Network Analyst and Toppgene databases were used to predict the core gene-related transcription factors,miRNAs and the treatments.Results There were 90 common genes in vitiligo and mitochondrial dysfunction,and 13 core genes were screened by analysis of protein-protein interaction.The biological processes of the common genes were mainly enriched in mitochondrial respiratory chain complex assembly,while the cellular compo-nents were mainly enriched in mitochondria.The molecular functions were mainly enriched in the activities of redox-driven transmembrane transporter and oxidoreductase,and KEGG was mainly enriched in respiratory electron transport.The transcription factors with high degree of interactions with the core genes included ATF1,KDM5A,KDM5B and PHF8,and the miRNAs with high in-teraction with core genes included hsa-mir-1-3p and hsa-mir-16-5p.The predicted effective drugs were lipoic acid and ubiquinols.Conclusions Mitochondrial dysfunction may contribute to patho-genesis of vitiligo by affecting biological processes,such as complex assembly and electron trans-port in the mitochondrial respiratory chain.Transcription factors,such as ATF1 and KDM5,and miRNAs,including miR-1 and miR-493,may play an important pathogenic role in vitiligo by in-teraction with key genes,such as NDUFA9,SURF1,NDUFS1,NDUFS4 and LRPPRC.关键词
白癜风/线粒体功能障碍/生物信息学/致病机制Key words
vitiligo/mitochondrial dysfunction/bioinformatics/pathogenic mechanism引用本文复制引用
张佳林,陈逴凡,徐英萍,史晓蔚,王天晶,任盈盈,罗光浦..线粒体功能障碍导致白癜风的机制:基于生物信息学方法[J].皮肤性病诊疗学杂志,2023,30(6):509-517,9.基金项目
广东省医学科研基金(B2020115,A2020614,B2022220) （B2020115,A2020614,B2022220）
广东省中医药局科研项目(20201230,20212157) （20201230,20212157）
