皮肤性病诊疗学杂志2023，Vol.30Issue(6)：529-533,5.DOI:10.3969/j.issn.1674-8468.2023.06.008
慢性光损伤皮肤的免疫微环境失衡研究进展
Advances in the imbalance of the immune microenvironment in the chronically photodam-aged skin
摘要
Abstract
In recent years,the mechanisms of repeated ultraviolet light(UV)radiation-in-duced spatial and temporal changes in the immune microenvironment and the imbalance are the hot research topic in the fields of skin,immunity,tumor and aging.Chronic UV radiation(UVR)can induce cellular phenotypic and functional changes in the skin microenvironment,and directly and indirectly alter the skin immune microenvironment.UVR induces immunosuppression,including activation of regulatory T cells and alterations in the number and function of antigen-presenting cells.The interactions among B cells,T cells,Langerhans cells and mast cells play an important role in UVR-induced immunosuppression.In addition,the effects of UVR on T cell co-inhibitory and co-stimulatory signals have been increasingly appreciated.In this paper,we review the recent progress in the imbalance of the immune microenvironment in the chronically photodamaged skin.关键词
日光紫外线/免疫微环境/皮肤免疫/肿瘤免疫/光老化Key words
solar ultraviolet light/immune microenvironment/skin immunity/tumor im-munity/photoaging引用本文复制引用
陈欣玲,孙钰,蒋雨含,郑跃..慢性光损伤皮肤的免疫微环境失衡研究进展[J].皮肤性病诊疗学杂志,2023,30(6):529-533,5.基金项目
广东省自然科学基金(2022A1515012253) （2022A1515012253）
